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The Alternative Pathway Is Necessary and Sufficient for Complement Activation by Anti-THSD7A Autoantibodies, Which Are Predominantly IgG4 in Membranous Nephropathy

Membranous nephropathy (MN) is an immune kidney disease characterized by glomerular subepithelial immune complexes (ICs) containing antigen, IgG, and products of complement activation. Whereas proteinuria is caused by complement-mediated podocyte injury, the pathways of complement activation remain...

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Detalles Bibliográficos
Autores principales:	Manral, Pallavi, Caza, Tiffany N., Storey, Aaron J., Beck, Laurence H., Borza, Dorin-Bogdan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301376/ https://www.ncbi.nlm.nih.gov/pubmed/35874690 http://dx.doi.org/10.3389/fimmu.2022.952235

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