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Non-Contact Intracardiac Potential Mapping Using Mesh-Based and Meshless Inverse Solvers

Atrial fibrillation (AF) is the most common cardiac dysrhythmia and percutaneous catheter ablation is widely used to treat it. Panoramic mapping with multi-electrode catheters has been used to identify ablation targets in persistent AF but is limited by poor contact and inadequate coverage of the le...

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Autores principales: Meng, Shu, Chamorro-Servent, Judit, Sunderland, Nicholas, Zhao, Jichao, Bear, Laura R., Lever, Nigel A., Sands, Gregory B., LeGrice, Ian J., Gillis, Anne M., Budgett, David M., Smaill, Bruce H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301455/
https://www.ncbi.nlm.nih.gov/pubmed/35874529
http://dx.doi.org/10.3389/fphys.2022.873630
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author Meng, Shu
Chamorro-Servent, Judit
Sunderland, Nicholas
Zhao, Jichao
Bear, Laura R.
Lever, Nigel A.
Sands, Gregory B.
LeGrice, Ian J.
Gillis, Anne M.
Budgett, David M.
Smaill, Bruce H.
author_facet Meng, Shu
Chamorro-Servent, Judit
Sunderland, Nicholas
Zhao, Jichao
Bear, Laura R.
Lever, Nigel A.
Sands, Gregory B.
LeGrice, Ian J.
Gillis, Anne M.
Budgett, David M.
Smaill, Bruce H.
author_sort Meng, Shu
collection PubMed
description Atrial fibrillation (AF) is the most common cardiac dysrhythmia and percutaneous catheter ablation is widely used to treat it. Panoramic mapping with multi-electrode catheters has been used to identify ablation targets in persistent AF but is limited by poor contact and inadequate coverage of the left atrial cavity. In this paper, we investigate the accuracy with which atrial endocardial surface potentials can be reconstructed from electrograms recorded with non-contact catheters. An in-silico approach was employed in which “ground-truth” surface potentials from experimental contact mapping studies and computer models were compared with inverse potential maps constructed by sampling the corresponding intracardiac field using virtual basket catheters. We demonstrate that it is possible to 1) specify the mixed boundary conditions required for mesh-based formulations of the potential inverse problem fully, and 2) reconstruct accurate inverse potential maps from recordings made with appropriately designed catheters. Accuracy improved when catheter dimensions were increased but was relatively stable when the catheter occupied >30% of atrial cavity volume. Independent of this, the capacity of non-contact catheters to resolve the complex atrial potential fields seen in reentrant atrial arrhythmia depended on the spatial distribution of electrodes on the surface bounding the catheter. Finally, we have shown that reliable inverse potential mapping is possible in near real-time with meshless methods that use the Method of Fundamental Solutions.
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spelling pubmed-93014552022-07-22 Non-Contact Intracardiac Potential Mapping Using Mesh-Based and Meshless Inverse Solvers Meng, Shu Chamorro-Servent, Judit Sunderland, Nicholas Zhao, Jichao Bear, Laura R. Lever, Nigel A. Sands, Gregory B. LeGrice, Ian J. Gillis, Anne M. Budgett, David M. Smaill, Bruce H. Front Physiol Physiology Atrial fibrillation (AF) is the most common cardiac dysrhythmia and percutaneous catheter ablation is widely used to treat it. Panoramic mapping with multi-electrode catheters has been used to identify ablation targets in persistent AF but is limited by poor contact and inadequate coverage of the left atrial cavity. In this paper, we investigate the accuracy with which atrial endocardial surface potentials can be reconstructed from electrograms recorded with non-contact catheters. An in-silico approach was employed in which “ground-truth” surface potentials from experimental contact mapping studies and computer models were compared with inverse potential maps constructed by sampling the corresponding intracardiac field using virtual basket catheters. We demonstrate that it is possible to 1) specify the mixed boundary conditions required for mesh-based formulations of the potential inverse problem fully, and 2) reconstruct accurate inverse potential maps from recordings made with appropriately designed catheters. Accuracy improved when catheter dimensions were increased but was relatively stable when the catheter occupied >30% of atrial cavity volume. Independent of this, the capacity of non-contact catheters to resolve the complex atrial potential fields seen in reentrant atrial arrhythmia depended on the spatial distribution of electrodes on the surface bounding the catheter. Finally, we have shown that reliable inverse potential mapping is possible in near real-time with meshless methods that use the Method of Fundamental Solutions. Frontiers Media S.A. 2022-07-07 /pmc/articles/PMC9301455/ /pubmed/35874529 http://dx.doi.org/10.3389/fphys.2022.873630 Text en Copyright © 2022 Meng, Chamorro-Servent, Sunderland, Zhao, Bear, Lever, Sands, LeGrice, Gillis, Budgett and Smaill. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Meng, Shu
Chamorro-Servent, Judit
Sunderland, Nicholas
Zhao, Jichao
Bear, Laura R.
Lever, Nigel A.
Sands, Gregory B.
LeGrice, Ian J.
Gillis, Anne M.
Budgett, David M.
Smaill, Bruce H.
Non-Contact Intracardiac Potential Mapping Using Mesh-Based and Meshless Inverse Solvers
title Non-Contact Intracardiac Potential Mapping Using Mesh-Based and Meshless Inverse Solvers
title_full Non-Contact Intracardiac Potential Mapping Using Mesh-Based and Meshless Inverse Solvers
title_fullStr Non-Contact Intracardiac Potential Mapping Using Mesh-Based and Meshless Inverse Solvers
title_full_unstemmed Non-Contact Intracardiac Potential Mapping Using Mesh-Based and Meshless Inverse Solvers
title_short Non-Contact Intracardiac Potential Mapping Using Mesh-Based and Meshless Inverse Solvers
title_sort non-contact intracardiac potential mapping using mesh-based and meshless inverse solvers
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301455/
https://www.ncbi.nlm.nih.gov/pubmed/35874529
http://dx.doi.org/10.3389/fphys.2022.873630
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