p53/sirtuin 1/NF-κB Signaling Axis in Chronic Inflammation and Maladaptive Kidney Repair After Cisplatin Nephrotoxicity

Chronic inflammation contributes to maladaptive kidney repair, but its regulation is unclear. Here, we report that sirtuin 1 (SIRT1) is downregulated after repeated low-dose cisplatin (RLDC) injury, and this downregulation leads to p65 acetylation and consequent NF-κB activation resulting in a persi...

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Detalles Bibliográficos
Autores principales: Fu, Ying, Wang, Ying, Liu, Yuxue, Tang, Chengyuan, Cai, Juan, Chen, Guochun, Dong, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301469/
https://www.ncbi.nlm.nih.gov/pubmed/35874713
http://dx.doi.org/10.3389/fimmu.2022.925738

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