Indole Diketopiperazine Alkaloids Isolated From the Marine-Derived Fungus Aspergillus chevalieri MCCC M23426

Two new indole diketopiperazines (1–2) obtained from the fermentation culture of a deep-sea-derived fungus Aspergillus chevalieri MCCC M23426, were characterized, together with nine biogenetic related compounds (3–11). The structures of 1–2 were assigned based on NMR, MS, NMR calculation, DP4+ analy...

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Detalles Bibliográficos
Autores principales: Lv, Dongli, Xia, Jinmei, Guan, Xiaoqing, Lai, Qiliang, Zhang, Beibei, Lin, Jianhui, Shao, Zongze, Luo, Sulan, Zhangsun, Dongting, Qin, Jiang-Jiang, Wang, Weiyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301495/
https://www.ncbi.nlm.nih.gov/pubmed/35875553
http://dx.doi.org/10.3389/fmicb.2022.950857
Descripción
Sumario:Two new indole diketopiperazines (1–2) obtained from the fermentation culture of a deep-sea-derived fungus Aspergillus chevalieri MCCC M23426, were characterized, together with nine biogenetic related compounds (3–11). The structures of 1–2 were assigned based on NMR, MS, NMR calculation, DP4+ analysis, and ECD calculation. The bioactive assay showed that compounds 1, 5–7 significantly inhibited the growth of Staphylococcus aureus. Meanwhile, compound 8 potently reduced the cell viability of gastric cancer cell MKN1 with an IC(50) value of 4.6 μM.

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