Indole Diketopiperazine Alkaloids Isolated From the Marine-Derived Fungus Aspergillus chevalieri MCCC M23426

Two new indole diketopiperazines (1–2) obtained from the fermentation culture of a deep-sea-derived fungus Aspergillus chevalieri MCCC M23426, were characterized, together with nine biogenetic related compounds (3–11). The structures of 1–2 were assigned based on NMR, MS, NMR calculation, DP4+ analy...

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Autores principales: Lv, Dongli, Xia, Jinmei, Guan, Xiaoqing, Lai, Qiliang, Zhang, Beibei, Lin, Jianhui, Shao, Zongze, Luo, Sulan, Zhangsun, Dongting, Qin, Jiang-Jiang, Wang, Weiyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301495/
https://www.ncbi.nlm.nih.gov/pubmed/35875553
http://dx.doi.org/10.3389/fmicb.2022.950857
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author Lv, Dongli
Xia, Jinmei
Guan, Xiaoqing
Lai, Qiliang
Zhang, Beibei
Lin, Jianhui
Shao, Zongze
Luo, Sulan
Zhangsun, Dongting
Qin, Jiang-Jiang
Wang, Weiyi
author_facet Lv, Dongli
Xia, Jinmei
Guan, Xiaoqing
Lai, Qiliang
Zhang, Beibei
Lin, Jianhui
Shao, Zongze
Luo, Sulan
Zhangsun, Dongting
Qin, Jiang-Jiang
Wang, Weiyi
author_sort Lv, Dongli
collection PubMed
description Two new indole diketopiperazines (1–2) obtained from the fermentation culture of a deep-sea-derived fungus Aspergillus chevalieri MCCC M23426, were characterized, together with nine biogenetic related compounds (3–11). The structures of 1–2 were assigned based on NMR, MS, NMR calculation, DP4+ analysis, and ECD calculation. The bioactive assay showed that compounds 1, 5–7 significantly inhibited the growth of Staphylococcus aureus. Meanwhile, compound 8 potently reduced the cell viability of gastric cancer cell MKN1 with an IC(50) value of 4.6 μM.
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spelling pubmed-93014952022-07-22 Indole Diketopiperazine Alkaloids Isolated From the Marine-Derived Fungus Aspergillus chevalieri MCCC M23426 Lv, Dongli Xia, Jinmei Guan, Xiaoqing Lai, Qiliang Zhang, Beibei Lin, Jianhui Shao, Zongze Luo, Sulan Zhangsun, Dongting Qin, Jiang-Jiang Wang, Weiyi Front Microbiol Microbiology Two new indole diketopiperazines (1–2) obtained from the fermentation culture of a deep-sea-derived fungus Aspergillus chevalieri MCCC M23426, were characterized, together with nine biogenetic related compounds (3–11). The structures of 1–2 were assigned based on NMR, MS, NMR calculation, DP4+ analysis, and ECD calculation. The bioactive assay showed that compounds 1, 5–7 significantly inhibited the growth of Staphylococcus aureus. Meanwhile, compound 8 potently reduced the cell viability of gastric cancer cell MKN1 with an IC(50) value of 4.6 μM. Frontiers Media S.A. 2022-07-07 /pmc/articles/PMC9301495/ /pubmed/35875553 http://dx.doi.org/10.3389/fmicb.2022.950857 Text en Copyright © 2022 Lv, Xia, Guan, Lai, Zhang, Lin, Shao, Luo, Zhangsun, Qin and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Lv, Dongli
Xia, Jinmei
Guan, Xiaoqing
Lai, Qiliang
Zhang, Beibei
Lin, Jianhui
Shao, Zongze
Luo, Sulan
Zhangsun, Dongting
Qin, Jiang-Jiang
Wang, Weiyi
Indole Diketopiperazine Alkaloids Isolated From the Marine-Derived Fungus Aspergillus chevalieri MCCC M23426
title Indole Diketopiperazine Alkaloids Isolated From the Marine-Derived Fungus Aspergillus chevalieri MCCC M23426
title_full Indole Diketopiperazine Alkaloids Isolated From the Marine-Derived Fungus Aspergillus chevalieri MCCC M23426
title_fullStr Indole Diketopiperazine Alkaloids Isolated From the Marine-Derived Fungus Aspergillus chevalieri MCCC M23426
title_full_unstemmed Indole Diketopiperazine Alkaloids Isolated From the Marine-Derived Fungus Aspergillus chevalieri MCCC M23426
title_short Indole Diketopiperazine Alkaloids Isolated From the Marine-Derived Fungus Aspergillus chevalieri MCCC M23426
title_sort indole diketopiperazine alkaloids isolated from the marine-derived fungus aspergillus chevalieri mccc m23426
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301495/
https://www.ncbi.nlm.nih.gov/pubmed/35875553
http://dx.doi.org/10.3389/fmicb.2022.950857
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