Cargando…

Intravenous Infusion of Autoserum-Expanded Autologous Mesenchymal Stem Cells in Patients With Chronic Brain Injury: Protocol for a Phase 2 Trial

BACKGROUND: Brain injuries resulting from motor vehicle accidents and falls, as well as hypoxic insults and other conditions, are one of the leading causes of disability and death in the world. Current treatments are limited but include continuous rehabilitation, especially for chronic brain injury....

Descripción completa

Detalles Bibliográficos
Autores principales:	Oka, Shinichi, Yamaki, Tomohiro, Sasaki, Masanori, Ukai, Ryo, Takemura, Mitsuhiro, Yokoyama, Takahiro, Kataoka-Sasaki, Yuko, Onodera, Rie, Ito, Yoichi M, Kobayashi, Shigeki, Kocsis, Jeffery D, Iwadate, Yasuo, Honmou, Osamu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	JMIR Publications 2022
Materias:	Protocol
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301565/ https://www.ncbi.nlm.nih.gov/pubmed/35793128 http://dx.doi.org/10.2196/37898

Ejemplares similares

Repeated infusion of mesenchymal stem cells maintain the condition to inhibit deteriorated motor function, leading to an extended lifespan in the SOD1G93A rat model of amyotrophic lateral sclerosis
por: Magota, Hirotoshi, et al.
Publicado: (2021)

Enhanced Network in Corticospinal Tracts after Infused Mesenchymal Stem Cells in Spinal Cord Injury
por: Hirota, Ryosuke, et al.
Publicado: (2022)

Prolonged lifespan in a spontaneously hypertensive rat (stroke prone) model following intravenous infusion of mesenchymal stem cells
por: Nakazaki, Masahito, et al.
Publicado: (2020)

Intravenous Infusion of Bone Marrow–Derived Mesenchymal Stem Cells Reduces Erectile Dysfunction Following Cavernous Nerve Injury in Rats
por: Matsuda, Yohei, et al.
Publicado: (2017)

Development of a Middle Cerebral Artery Occlusion Model in the Nonhuman Primate and a Safety Study of I.V. Infusion of Human Mesenchymal Stem Cells
por: Sasaki, Masanori, et al.
Publicado: (2011)

The Impact of Purple-Flesh Potato (Solanum tuberosum L.) cv. “Shadow Queen” on Minor Health Complaints in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Study
por: Maeda-Yamamoto, Mari, et al.
Publicado: (2022)

Possible role of intravenous administration of mesenchymal stem cells to alleviate interstitial cystitis/bladder pain syndrome in a Toll-like receptor-7 agonist-induced experimental animal model in rat
por: Tabata, Hidetoshi, et al.
Publicado: (2021)

Allergic diseases of the skin and drug allergies – 2024. Autoserum therapy in autologous serum skin test positive patients of chronic spontaneous urticaria
por: Sharma, Nidhi
Publicado: (2013)

Autoserum: An Optimal Supplement for Bone Marrow Mesenchymal Stem Cells of Liver-Injured Rats
por: Zhang, Qinglin, et al.
Publicado: (2015)

Intravenous infusion of bone marrow-derived mesenchymal stem cells improves tissue perfusion in a rat hindlimb ischemia model
por: Maeda, Shusaku, et al.
Publicado: (2022)

Mesenchymal Stem Cell Transplantation for Spinal Cord Injury: Current Status and Prospects
por: Hirota, Ryosuke, et al.
Publicado: (2023)

Convergence of Cells from the Progenitor Fraction of Adult Olfactory Bulb Tissue to Remyelinating Glia in Demyelinating Spinal Cord Lesions
por: Markakis, Eleni A., et al.
Publicado: (2009)

CNPase Expression in Olfactory Ensheathing Cells
por: Radtke, Christine, et al.
Publicado: (2011)

Actin Alpha 2, Smooth Muscle (ACTA2) Is Involved in the Migratory Potential of Malignant Gliomas, and Its Increased Expression at Recurrence Is a Significant Adverse Prognostic Factor
por: Hoshimaru, Takumi, et al.
Publicado: (2023)

STMO-3 Mid- to long-term outcome of supratotal resection of IDH1 wild-type glioblastoma based on 11C-methionine PET: a retrospective, single-center study
por: Hirono, Seiichiro, et al.
Publicado: (2021)

Oncological and functional outcomes of supratotal resection of IDH1 wild-type glioblastoma based on (11)C-methionine PET: a retrospective, single-center study
por: Hirono, Seiichiro, et al.
Publicado: (2021)

Intrabronchial Infusion of Autologous Blood Plus Thrombin for Intractable Pneumothorax After Bronchial Occlusion Using Silicon Spigots: A Case Series of 9 Patients With Emphysema
por: Mizumori, Yasuyuki, et al.
Publicado: (2016)

Autologous antibody to src-homology 3-domain GRB2-like 1 specifically increases in the sera of patients with low-grade gliomas
por: Matsutani, Tomoo, et al.
Publicado: (2012)

Detection of local and remote cellular damage caused by spinal cord and peripheral nerve injury using a heat shock signaling reporter system
por: Hashimoto-Torii, Kazue, et al.
Publicado: (2018)

Myeloablative treatment supported by autologous stem cell infusion with neuroblastoma.
por: Ryu, Kyung Ha, et al.
Publicado: (2003)

Infusion of Autologous Retrodifferentiated Stem Cells into Patients with Beta-Thalassemia
por: Abuljadayel, Ilham Saleh, et al.
Publicado: (2006)

Prediction of voluntary movements of the upper extremities by resting state‐brain regional glucose metabolism in patients with chronic severe brain injury: A pilot study
por: Yamaki, Tomohiro, et al.
Publicado: (2023)

An aberrant venous channel mimicking the perilabyrinthine cells in the petrous bone of a patient with vestibular schwannoma: illustrative case
por: Ito, Masato, et al.
Publicado: (2021)

Literature reviews on coping behavior of women with menopausal symptoms and menopausal disorders
por: Yamaki, Chihiro, et al.
Publicado: (2023)

Prehospital stroke-scale machine-learning model predicts the need for surgical intervention
por: Yoshida, Yoichi, et al.
Publicado: (2023)

10th Workshop on Radiation Detectors and their Uses
por: Iguchi, T, et al.
Publicado: (1996)

Transarterial embolization for falx dural arteriovenous fistula through the artery of Davidoff and Schechter: A case report
por: Sugiyama, Tomohiro, et al.
Publicado: (2021)

Ruptured bilateral middle cerebral artery aneurysms diagnosed based on cerebral vasospasm-associated ischemic symptoms: A case report
por: Yoshida, Yoichi, et al.
Publicado: (2022)

Two Patients with Reversible Cerebral Vasoconstriction after Carotid Artery Stenting
por: Yoshida, Yoichi, et al.
Publicado: (2021)

Phase I Study of Paclitaxel by Three‐hour Infusion: Hypotension Just after Infusion Is One of the Major Dose‐limiting Toxicities
por: Tamura, Tomohide, et al.
Publicado: (1995)

A prehospital diagnostic algorithm for strokes using machine learning: a prospective observational study
por: Hayashi, Yosuke, et al.
Publicado: (2021)

Epithelial-mesenchymal transition in glioblastoma progression
por: IWADATE, YASUO
Publicado: (2016)

Plasticity in Glioma Stem Cell Phenotype and Its Therapeutic Implication
por: IWADATE, Yasuo
Publicado: (2018)

Arachnoid cyst alone causes hemifacial spasm: illustrative case
por: Ozaki, Ko, et al.
Publicado: (2022)

The impact of repeated autologous infusion of haematopoietic stem cells in patients with liver insufficiency
por: Zekri, Abdel-Rahman N., et al.
Publicado: (2015)

Small extracellular vesicles released by infused mesenchymal stromal cells target M2 macrophages and promote TGF‐β upregulation, microvascular stabilization and functional recovery in a rodent model of severe spinal cord injury
por: Nakazaki, Masahito, et al.
Publicado: (2021)

Carotid Artery Stenting for Patients with Radiation-Induced Carotid Artery Stenosis
por: Yoshida, Yoichi, et al.
Publicado: (2022)

8th Workshop on Radiation Detectors and their Uses
por: Iguchi, T, et al.
Publicado: (1994)

7th Workshop on Radiation Detectors and their Uses
por: Iguchi, T, et al.
Publicado: (1993)

9th Workshop on Radiation Detectors and their Uses
por: Iguchi, T, et al.
Publicado: (1995)

Cannot write session to /tmp/vufind_sessions/sess_3ncvsriokot1r1i79ghnld5o6e