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Serum interleukin-23 levels: relation to depression, anxiety, and disease activity in psoriatic arthritis patients

OBJECTIVES: Assessment of serum levels of IL-23 in PsA patients and its correlation with depression, anxiety, and disease activity. METHODS: Eighty psoriatic arthritis (PsA) patients and eighty healthy volunteers matched for age and gender were included in this observational case–control study. All...

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Autores principales: Tabra, Samar Abdalhamed, abd Elghany, Salwa Elmorsy, Amer, Reham A., Fouda, Mohamed H., Abu-Zaid, Mohammed Hassan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301620/
https://www.ncbi.nlm.nih.gov/pubmed/35861930
http://dx.doi.org/10.1007/s10067-022-06300-1
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author Tabra, Samar Abdalhamed
abd Elghany, Salwa Elmorsy
Amer, Reham A.
Fouda, Mohamed H.
Abu-Zaid, Mohammed Hassan
author_facet Tabra, Samar Abdalhamed
abd Elghany, Salwa Elmorsy
Amer, Reham A.
Fouda, Mohamed H.
Abu-Zaid, Mohammed Hassan
author_sort Tabra, Samar Abdalhamed
collection PubMed
description OBJECTIVES: Assessment of serum levels of IL-23 in PsA patients and its correlation with depression, anxiety, and disease activity. METHODS: Eighty psoriatic arthritis (PsA) patients and eighty healthy volunteers matched for age and gender were included in this observational case–control study. All participants suspected to detailed history, clinical assessment, PsA activity using Disease Activity Index for Psoriatic Arthritis (DAPSA) score, the severity and extent of psoriasis was assessed by the Psoriasis Area and Severity Index (PASI), and ultrasonographic assessments of the entheses were examined according to the Madrid Sonographic Enthesitis Index (MASEI). Depression and anxiety were assessed by Hospital Anxiety and Depression Scale (HADS). Serum IL-23 was measured and correlated with disease activity, depression, and anxiety. RESULTS: There was no significant difference between patients and controls regarding demographic data. Thirty-six PsA patients (45%) had anxiety and 28 patients (35%) had depression, while in the control group, 16 persons (20%) had anxiety and 12 (15%) had depression, with significant differences between the 2 groups (p < 0.0001). There were significant differences in HADS anxiety and depression scores between patients and controls with significant positive correlations between HADS depression, anxiety scores and IL-23, DAPSA, PASI, and MASEI scores (p < 0.05). IL-23 was positively correlated with DAPSA, PASI, and HADS scores; we observed that interleukin 23, higher DAPSA, and PASI were independently associated with depression and anxiety. CONCLUSION: Serum interleukin-23 levels were elevated in PsA patients and were found to be correlated with depression, anxiety, and disease activity.
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spelling pubmed-93016202022-07-21 Serum interleukin-23 levels: relation to depression, anxiety, and disease activity in psoriatic arthritis patients Tabra, Samar Abdalhamed abd Elghany, Salwa Elmorsy Amer, Reham A. Fouda, Mohamed H. Abu-Zaid, Mohammed Hassan Clin Rheumatol Original Article OBJECTIVES: Assessment of serum levels of IL-23 in PsA patients and its correlation with depression, anxiety, and disease activity. METHODS: Eighty psoriatic arthritis (PsA) patients and eighty healthy volunteers matched for age and gender were included in this observational case–control study. All participants suspected to detailed history, clinical assessment, PsA activity using Disease Activity Index for Psoriatic Arthritis (DAPSA) score, the severity and extent of psoriasis was assessed by the Psoriasis Area and Severity Index (PASI), and ultrasonographic assessments of the entheses were examined according to the Madrid Sonographic Enthesitis Index (MASEI). Depression and anxiety were assessed by Hospital Anxiety and Depression Scale (HADS). Serum IL-23 was measured and correlated with disease activity, depression, and anxiety. RESULTS: There was no significant difference between patients and controls regarding demographic data. Thirty-six PsA patients (45%) had anxiety and 28 patients (35%) had depression, while in the control group, 16 persons (20%) had anxiety and 12 (15%) had depression, with significant differences between the 2 groups (p < 0.0001). There were significant differences in HADS anxiety and depression scores between patients and controls with significant positive correlations between HADS depression, anxiety scores and IL-23, DAPSA, PASI, and MASEI scores (p < 0.05). IL-23 was positively correlated with DAPSA, PASI, and HADS scores; we observed that interleukin 23, higher DAPSA, and PASI were independently associated with depression and anxiety. CONCLUSION: Serum interleukin-23 levels were elevated in PsA patients and were found to be correlated with depression, anxiety, and disease activity. Springer International Publishing 2022-07-21 2022 /pmc/articles/PMC9301620/ /pubmed/35861930 http://dx.doi.org/10.1007/s10067-022-06300-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Tabra, Samar Abdalhamed
abd Elghany, Salwa Elmorsy
Amer, Reham A.
Fouda, Mohamed H.
Abu-Zaid, Mohammed Hassan
Serum interleukin-23 levels: relation to depression, anxiety, and disease activity in psoriatic arthritis patients
title Serum interleukin-23 levels: relation to depression, anxiety, and disease activity in psoriatic arthritis patients
title_full Serum interleukin-23 levels: relation to depression, anxiety, and disease activity in psoriatic arthritis patients
title_fullStr Serum interleukin-23 levels: relation to depression, anxiety, and disease activity in psoriatic arthritis patients
title_full_unstemmed Serum interleukin-23 levels: relation to depression, anxiety, and disease activity in psoriatic arthritis patients
title_short Serum interleukin-23 levels: relation to depression, anxiety, and disease activity in psoriatic arthritis patients
title_sort serum interleukin-23 levels: relation to depression, anxiety, and disease activity in psoriatic arthritis patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301620/
https://www.ncbi.nlm.nih.gov/pubmed/35861930
http://dx.doi.org/10.1007/s10067-022-06300-1
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