Tricyclic Aza-Andrographolide Derivatives from Late-Stage Hydroamination and Their Anti-human Coronavirus (Anti-HCoV) Activity

[Image: see text] A late-stage functionalization (LSF) of the natural product andrographolide for the efficient assembly of a range of structurally interesting and diverse tricyclic-aza derivatives was developed. The key to the diversification is a photo-catalyzed intramolecular hydroamination react...

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Autores principales: Che, Chao, Jiang, Ding, Zhang, Jiayin, Xing, Qi, Li, Ting, Zhao, Yi, Guan, Liangyu, Chen, Huangcan, Xiang, Dehu, Di, Man, Zhu, Zhendong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301648/
https://www.ncbi.nlm.nih.gov/pubmed/35874238
http://dx.doi.org/10.1021/acsomega.2c02979
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author Che, Chao
Jiang, Ding
Zhang, Jiayin
Xing, Qi
Li, Ting
Zhao, Yi
Guan, Liangyu
Chen, Huangcan
Xiang, Dehu
Di, Man
Zhu, Zhendong
author_facet Che, Chao
Jiang, Ding
Zhang, Jiayin
Xing, Qi
Li, Ting
Zhao, Yi
Guan, Liangyu
Chen, Huangcan
Xiang, Dehu
Di, Man
Zhu, Zhendong
author_sort Che, Chao
collection PubMed
description [Image: see text] A late-stage functionalization (LSF) of the natural product andrographolide for the efficient assembly of a range of structurally interesting and diverse tricyclic-aza derivatives was developed. The key to the diversification is a photo-catalyzed intramolecular hydroamination reaction, and acridinium derivatives were demonstrated to be the optimal catalysts. Additionally, the synthesized tricyclic aza-andrographolide derivatives were found to inhibit human coronavirus with high potency.
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spelling pubmed-93016482022-07-22 Tricyclic Aza-Andrographolide Derivatives from Late-Stage Hydroamination and Their Anti-human Coronavirus (Anti-HCoV) Activity Che, Chao Jiang, Ding Zhang, Jiayin Xing, Qi Li, Ting Zhao, Yi Guan, Liangyu Chen, Huangcan Xiang, Dehu Di, Man Zhu, Zhendong ACS Omega [Image: see text] A late-stage functionalization (LSF) of the natural product andrographolide for the efficient assembly of a range of structurally interesting and diverse tricyclic-aza derivatives was developed. The key to the diversification is a photo-catalyzed intramolecular hydroamination reaction, and acridinium derivatives were demonstrated to be the optimal catalysts. Additionally, the synthesized tricyclic aza-andrographolide derivatives were found to inhibit human coronavirus with high potency. American Chemical Society 2022-07-07 /pmc/articles/PMC9301648/ /pubmed/35874238 http://dx.doi.org/10.1021/acsomega.2c02979 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Che, Chao
Jiang, Ding
Zhang, Jiayin
Xing, Qi
Li, Ting
Zhao, Yi
Guan, Liangyu
Chen, Huangcan
Xiang, Dehu
Di, Man
Zhu, Zhendong
Tricyclic Aza-Andrographolide Derivatives from Late-Stage Hydroamination and Their Anti-human Coronavirus (Anti-HCoV) Activity
title Tricyclic Aza-Andrographolide Derivatives from Late-Stage Hydroamination and Their Anti-human Coronavirus (Anti-HCoV) Activity
title_full Tricyclic Aza-Andrographolide Derivatives from Late-Stage Hydroamination and Their Anti-human Coronavirus (Anti-HCoV) Activity
title_fullStr Tricyclic Aza-Andrographolide Derivatives from Late-Stage Hydroamination and Their Anti-human Coronavirus (Anti-HCoV) Activity
title_full_unstemmed Tricyclic Aza-Andrographolide Derivatives from Late-Stage Hydroamination and Their Anti-human Coronavirus (Anti-HCoV) Activity
title_short Tricyclic Aza-Andrographolide Derivatives from Late-Stage Hydroamination and Their Anti-human Coronavirus (Anti-HCoV) Activity
title_sort tricyclic aza-andrographolide derivatives from late-stage hydroamination and their anti-human coronavirus (anti-hcov) activity
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301648/
https://www.ncbi.nlm.nih.gov/pubmed/35874238
http://dx.doi.org/10.1021/acsomega.2c02979
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