Exchange Broadening Underlies the Enhancement of IDE-Dependent Degradation of Insulin by Anionic Membranes

[Image: see text] Insulin-degrading enzyme (IDE) is an evolutionarily conserved ubiquitous zinc metalloprotease implicated in the efficient degradation of insulin monomer. However, IDE also degrades monomers of amyloidogenic peptides associated with disease, complicating the development of IDE inhib...

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Detalles Bibliográficos
Autores principales: Zheng, Qiuchen, Lee, Bethany, Kebede, Micheal T., Ivancic, Valerie A., Kemeh, Merc M., Brito, Henrique Lemos, Spratt, Donald E., Lazo, Noel D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301717/
https://www.ncbi.nlm.nih.gov/pubmed/35874268
http://dx.doi.org/10.1021/acsomega.2c02747

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301717/
https://www.ncbi.nlm.nih.gov/pubmed/35874268
http://dx.doi.org/10.1021/acsomega.2c02747

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