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Estimation of Early Graft Function Using the BETA-2 Score Following Clinical Islet Transplantation

Little is known about how early islet graft function evolves in the clinical setting. The BETA-2 score is a validated index of islet function that can be calculated from a single blood sample and lends itself to frequent monitoring of graft function. In this study, we characterized early graft funct...

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Autores principales: Lam, Anna, Oram, Richard A., Forbes, Shareen, Olateju, Tolu, Malcolm, Andrew J., Imes, Sharleen, Shapiro, A. M. James, Senior, Peter A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301872/
https://www.ncbi.nlm.nih.gov/pubmed/35874309
http://dx.doi.org/10.3389/ti.2022.10335
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author Lam, Anna
Oram, Richard A.
Forbes, Shareen
Olateju, Tolu
Malcolm, Andrew J.
Imes, Sharleen
Shapiro, A. M. James
Senior, Peter A.
author_facet Lam, Anna
Oram, Richard A.
Forbes, Shareen
Olateju, Tolu
Malcolm, Andrew J.
Imes, Sharleen
Shapiro, A. M. James
Senior, Peter A.
author_sort Lam, Anna
collection PubMed
description Little is known about how early islet graft function evolves in the clinical setting. The BETA-2 score is a validated index of islet function that can be calculated from a single blood sample and lends itself to frequent monitoring of graft function. In this study, we characterized early graft function by calculating weekly BETA-2 score in recipients who achieved insulin independence after single transplant (group 1, n = 8) compared to recipients who required a second transplant before achieving insulin independence (group 2, n = 7). We also determined whether graft function 1-week post-transplant was associated with insulin independence in individuals who received initial transplant between 2000–2017 (n = 125). Our results show that graft function increased rapidly reaching a plateau 4–6 weeks post-transplant. The BETA-2 score was higher in group 1 compared to group 2 as early as 1-week post-transplant (15 + 3 vs. 9 + 2, p = 0.001). In an unselected cohort, BETA-2 at 1-week post-transplant was associated with graft survival as defined by insulin independence during median follow up of 12 months (range 2–119 months) with greater survival among those with BETA-2 score >10 (p < 0.001, log-rank test). These findings suggest that primary graft function is established within 4–6 weeks post-transplant and graft function at 1-week post-transplant predicts long-term transplant outcomes.
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spelling pubmed-93018722022-07-22 Estimation of Early Graft Function Using the BETA-2 Score Following Clinical Islet Transplantation Lam, Anna Oram, Richard A. Forbes, Shareen Olateju, Tolu Malcolm, Andrew J. Imes, Sharleen Shapiro, A. M. James Senior, Peter A. Transpl Int Health Archive Little is known about how early islet graft function evolves in the clinical setting. The BETA-2 score is a validated index of islet function that can be calculated from a single blood sample and lends itself to frequent monitoring of graft function. In this study, we characterized early graft function by calculating weekly BETA-2 score in recipients who achieved insulin independence after single transplant (group 1, n = 8) compared to recipients who required a second transplant before achieving insulin independence (group 2, n = 7). We also determined whether graft function 1-week post-transplant was associated with insulin independence in individuals who received initial transplant between 2000–2017 (n = 125). Our results show that graft function increased rapidly reaching a plateau 4–6 weeks post-transplant. The BETA-2 score was higher in group 1 compared to group 2 as early as 1-week post-transplant (15 + 3 vs. 9 + 2, p = 0.001). In an unselected cohort, BETA-2 at 1-week post-transplant was associated with graft survival as defined by insulin independence during median follow up of 12 months (range 2–119 months) with greater survival among those with BETA-2 score >10 (p < 0.001, log-rank test). These findings suggest that primary graft function is established within 4–6 weeks post-transplant and graft function at 1-week post-transplant predicts long-term transplant outcomes. Frontiers Media S.A. 2022-07-06 /pmc/articles/PMC9301872/ /pubmed/35874309 http://dx.doi.org/10.3389/ti.2022.10335 Text en Copyright © 2022 Lam, Oram, Forbes, Olateju, Malcolm, Imes, Shapiro and Senior. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Health Archive
Lam, Anna
Oram, Richard A.
Forbes, Shareen
Olateju, Tolu
Malcolm, Andrew J.
Imes, Sharleen
Shapiro, A. M. James
Senior, Peter A.
Estimation of Early Graft Function Using the BETA-2 Score Following Clinical Islet Transplantation
title Estimation of Early Graft Function Using the BETA-2 Score Following Clinical Islet Transplantation
title_full Estimation of Early Graft Function Using the BETA-2 Score Following Clinical Islet Transplantation
title_fullStr Estimation of Early Graft Function Using the BETA-2 Score Following Clinical Islet Transplantation
title_full_unstemmed Estimation of Early Graft Function Using the BETA-2 Score Following Clinical Islet Transplantation
title_short Estimation of Early Graft Function Using the BETA-2 Score Following Clinical Islet Transplantation
title_sort estimation of early graft function using the beta-2 score following clinical islet transplantation
topic Health Archive
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301872/
https://www.ncbi.nlm.nih.gov/pubmed/35874309
http://dx.doi.org/10.3389/ti.2022.10335
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