GRP75-driven, cell-cycle-dependent macropinocytosis of Tat/pDNA-Ca(2+) nanoparticles underlies distinct gene therapy effect in ovarian cancer

Practice of tumor-targeted suicide gene therapy is hampered by unsafe and low efficient delivery of plasmid DNA (pDNA). Using HIV-Tat-derived peptide (Tat) to non-covalently form Tat/pDNA complexes advances the delivery performance. However, this innovative approach is still limited by intracellular...

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Detalles Bibliográficos
Autores principales: Su, Linjia, Sun, Zhe, Qi, Fangzheng, Su, Huishan, Qian, Luomeng, Li, Jing, Zuo, Liang, Huang, Jinhai, Yu, Zhilin, Li, Jinping, Chen, Zhinan, Zhang, Sihe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301890/
https://www.ncbi.nlm.nih.gov/pubmed/35858873
http://dx.doi.org/10.1186/s12951-022-01530-6

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