Cargando…

The ADP-Heptose Biosynthesis Enzyme GmhB is a Conserved Gram-Negative Bacteremia Fitness Factor

Klebsiella pneumoniae is a leading cause of Gram-negative bacteremia, which is a major source of morbidity and mortality worldwide. Gram-negative bacteremia requires three major steps: primary site infection, dissemination to the blood, and bloodstream survival. Because K. pneumoniae is a leading ca...

Descripción completa

Detalles Bibliográficos
Autores principales:	Holmes, Caitlyn L., Smith, Sara N., Gurczynski, Stephen J., Severin, Geoffrey B., Unverdorben, Lavinia V., Vornhagen, Jay, Mobley, Harry L. T., Bachman, Michael A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2022
Materias:	Molecular Pathogenesis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9302095/ https://www.ncbi.nlm.nih.gov/pubmed/35762751 http://dx.doi.org/10.1128/iai.00224-22

Ejemplares similares

Helicobacter pylori GmhB enzyme involved in ADP-heptose biosynthesis pathway is essential for lipopolysaccharide biosynthesis and bacterial virulence
por: Chiu, Sue-Fen, et al.
Publicado: (2021)

The Klebsiella pneumoniae ter Operon Enhances Stress Tolerance
por: Mason, Sophia, et al.
Publicado: (2023)

A Bittersweet Kiss of Gram-Negative Bacteria: The Role of ADP-Heptose in the Pathogenesis of Infection
por: Sidor, Karolina, et al.
Publicado: (2023)

Functional and structural studies on the Neisseria gonorrhoeae GmhA, the first enzyme in the glycero‐manno‐heptose biosynthesis pathways, demonstrate a critical role in lipooligosaccharide synthesis and gonococcal viability
por: Wierzbicki, Igor H., et al.
Publicado: (2017)

ALPK1: a pattern recognition receptor for bacterial ADP-heptose
por: Cong, Yingzi
Publicado: (2018)

Klebsiella pneumoniae causes bacteremia using factors that mediate tissue-specific fitness and resistance to oxidative stress
por: Holmes, Caitlyn L., et al.
Publicado: (2023)

Helicobacter pylori Modulates Heptose Metabolite Biosynthesis and Heptose-Dependent Innate Immune Host Cell Activation by Multiple Mechanisms
por: Hauke, Martina, et al.
Publicado: (2023)

ADP heptose, a novel pathogen-associated molecular pattern identified in Helicobacter pylori
por: Pfannkuch, Lennart, et al.
Publicado: (2019)

Activation of Purine Biosynthesis Suppresses the Sensitivity of E. coli gmhA Mutant to Antibiotics
por: Seregina, Tatiana A., et al.
Publicado: (2023)

Cross Talk between MarR-Like Transcription Factors Coordinates the Regulation of Motility in Uropathogenic Escherichia coli
por: Luterbach, Courtney L., et al.
Publicado: (2018)

Convergent Evolution of Antibiotic Tolerance in Patients with Persistent Methicillin-Resistant Staphylococcus aureus Bacteremia
por: Elgrail, Mitra M., et al.
Publicado: (2022)

Proteomic Profiling of Outer Membrane Vesicles Released by Escherichia coli LPS Mutants Defective in Heptose Biosynthesis
por: Chiu, Yaw-Kwan, et al.
Publicado: (2022)

A23 INTESTINAL STEM CELL REGULATION BY THE BACTERIAL METABOLITE ADP-HEPTOSE VIA ACTIVATION OF THE ALPK1-TIFA SIGNALLING PATHWAY
por: Goyal, S, et al.
Publicado: (2023)

Electrophysiological Analysis Shows Dizziness as the First Symptom in Human T Cell Lymphotropic Virus Type-Associated Myelopathy/Tropical Spastic Paraparesis
por: Labanca, Ludimila, et al.
Publicado: (2015)

Malnutrition in HIV-Infected Children Is an Indicator of Severe Disease with an Impaired Response to Antiretroviral Therapy
por: Muenchhoff, Maximilian, et al.
Publicado: (2018)

Restoring Cytokine Balance in HIV-Positive Individuals with Low CD4 T Cell Counts
por: Valdivia, Anddre, et al.
Publicado: (2017)

Toll‐like receptor‐1, ‐2, and ‐6 genotypes in relation to salivary human beta‐defensin‐1, ‐2, ‐3 and human neutrophilic peptide‐1
por: Gürsoy, Mervi, et al.
Publicado: (2022)

Downregulation of miRNA‐26 in chronic periodontitis interferes with innate immune responses and cell migration by targeting phospholipase C beta 1
por: Uttamani, Juhi R., et al.
Publicado: (2022)

Akkermansia muciniphila upregulates genes involved in maintaining the intestinal barrier function via ADP-heptose-dependent activation of the ALPK1/TIFA pathway
por: Martin-Gallausiaux, Camille, et al.
Publicado: (2022)

In vitro kinase assay reveals ADP-heptose-dependent ALPK1 autophosphorylation and altered kinase activity of disease-associated ALPK1 mutants
por: García-Weber, Diego, et al.
Publicado: (2023)

The crystal structure of the Y140F mutant of ADP-l-glycero-d-manno-heptose 6-epimerase bound to ADP-β-d-mannose suggests a one base mechanism
por: Kowatz, Thomas, et al.
Publicado: (2010)

ALPK1 controls TIFA/TRAF6-dependent innate immunity against heptose-1,7-bisphosphate of gram-negative bacteria
por: Milivojevic, Milica, et al.
Publicado: (2017)

A conservative distribution of tridomain NDP-heptose synthetases in actinobacteria
por: Tang, Yue, et al.
Publicado: (2021)

Co-ordinated control of the ADP-heptose/ALPK1 signalling network by the E3 ligases TRAF6, TRAF2/c-IAP1 and LUBAC
por: Snelling, Tom, et al.
Publicado: (2022)

A functional menadione biosynthesis pathway is required for capsule production by Staphylococcus aureus
por: Altwiley, Dina, et al.
Publicado: (2021)

Gram-negative bacteremia induces greater magnitude of inflammatory response than Gram-positive bacteremia
por: Abe, Ryuzo, et al.
Publicado: (2010)

Combined comparative genomics and clinical modeling reveals plasmid-encoded genes are independently associated with Klebsiella infection
por: Vornhagen, Jay, et al.
Publicado: (2022)

Utility of Human In Vitro Data in Risk Assessments of Influenza A Virus Using the Ferret Model
por: Creager, Hannah M., et al.
Publicado: (2023)

Helicobacter pylori modulates host cell responses by CagT4SS-dependent translocation of an intermediate metabolite of LPS inner core heptose biosynthesis
por: Stein, Saskia C., et al.
Publicado: (2017)

Heptose Sounds the Alarm: Innate Sensing of a Bacterial Sugar Stimulates Immunity
por: Gaudet, Ryan G., et al.
Publicado: (2016)

Preferential formation of specific hexose and heptose in the formose reaction under microwave irradiation
por: Hashidzume, Akihito, et al.
Publicado: (2023)

Vaccinia Virus Inhibits NF-κB-Dependent Gene Expression Downstream of p65 Translocation
por: Sumner, Rebecca P., et al.
Publicado: (2014)

Deep cerebral venous abnormalities in premature babies with GMH-IVH: a single-centre retrospective study
por: Kent, Thomas, et al.
Publicado: (2023)

Regional Brain Recovery from Acute Synaptic Injury in Simian Immunodeficiency Virus-Infected Rhesus Macaques Associates with Heme Oxygenase Isoform Expression
por: Garcia-Mesa, Yoelvis, et al.
Publicado: (2020)

Characterization of an Emergent Chicken H3N8 Influenza Virus in Southern China: a Potential Threat to Public Health
por: Chen, Peiwen, et al.
Publicado: (2023)

The Klebsiella pneumoniae citrate synthase gene, gltA, influences site specific fitness during infection
por: Vornhagen, Jay, et al.
Publicado: (2019)

Differential Disease Susceptibilities in Experimentally Reptarenavirus-Infected Boa Constrictors and Ball Pythons
por: Stenglein, Mark D., et al.
Publicado: (2017)

Conserved metabolic regulator ArcA responds to oxygen availability, iron limitation, and cell envelope perturbations during bacteremia
por: Brown, Aric N., et al.
Publicado: (2023)

Collaboration of a Detrimental HLA-B*35:01 Allele with HLA-A*24:02 in Coevolution of HIV-1 with T Cells Leading to Poorer Clinical Outcomes
por: Kuse, Nozomi, et al.
Publicado: (2021)

Deletion of the African Swine Fever Virus Gene DP148R Does Not Reduce Virus Replication in Culture but Reduces Virus Virulence in Pigs and Induces High Levels of Protection against Challenge
por: Reis, Ana L., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_fk4hon3ns1f2u5oalshmp77u8f