Aqueous dispersions of oxygen nanobubbles for potential application in inhalation therapy

Inhalation is a non-invasive method of local drug delivery to the respiratory system. This study analyzed the potential use of aqueous dispersion of oxygen nanobubbles (ADON) as a drug carrier with the additional function of oxygen supplementation to diseased lungs. The suitability of the membrane-b...

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Autores principales: Odziomek, Marcin, Ulatowski, Karol, Dobrowolska, Katarzyna, Górniak, Izabela, Sobieszuk, Paweł, Sosnowski, Tomasz R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9302230/
https://www.ncbi.nlm.nih.gov/pubmed/35864438
http://dx.doi.org/10.1038/s41598-022-16720-3
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author Odziomek, Marcin
Ulatowski, Karol
Dobrowolska, Katarzyna
Górniak, Izabela
Sobieszuk, Paweł
Sosnowski, Tomasz R.
author_facet Odziomek, Marcin
Ulatowski, Karol
Dobrowolska, Katarzyna
Górniak, Izabela
Sobieszuk, Paweł
Sosnowski, Tomasz R.
author_sort Odziomek, Marcin
collection PubMed
description Inhalation is a non-invasive method of local drug delivery to the respiratory system. This study analyzed the potential use of aqueous dispersion of oxygen nanobubbles (ADON) as a drug carrier with the additional function of oxygen supplementation to diseased lungs. The suitability of the membrane-based method of ADON preparation and, next, the stability of ADON properties during storage and after aerosolization in nebulizers of various designs (jet, ultrasonic, and two vibrating mesh devices) was investigated. The increased oxygen content in the aerosol generated in two mesh nebulizers suggests that the proposed concept may be helpful in the oxygen supplementation during drug delivery by aerosol inhalation without using an additional oxygen source. This application can increase the overall effectiveness of lung disease treatment and pulmonary rehabilitation.
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spelling pubmed-93022302022-07-22 Aqueous dispersions of oxygen nanobubbles for potential application in inhalation therapy Odziomek, Marcin Ulatowski, Karol Dobrowolska, Katarzyna Górniak, Izabela Sobieszuk, Paweł Sosnowski, Tomasz R. Sci Rep Article Inhalation is a non-invasive method of local drug delivery to the respiratory system. This study analyzed the potential use of aqueous dispersion of oxygen nanobubbles (ADON) as a drug carrier with the additional function of oxygen supplementation to diseased lungs. The suitability of the membrane-based method of ADON preparation and, next, the stability of ADON properties during storage and after aerosolization in nebulizers of various designs (jet, ultrasonic, and two vibrating mesh devices) was investigated. The increased oxygen content in the aerosol generated in two mesh nebulizers suggests that the proposed concept may be helpful in the oxygen supplementation during drug delivery by aerosol inhalation without using an additional oxygen source. This application can increase the overall effectiveness of lung disease treatment and pulmonary rehabilitation. Nature Publishing Group UK 2022-07-21 /pmc/articles/PMC9302230/ /pubmed/35864438 http://dx.doi.org/10.1038/s41598-022-16720-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Odziomek, Marcin
Ulatowski, Karol
Dobrowolska, Katarzyna
Górniak, Izabela
Sobieszuk, Paweł
Sosnowski, Tomasz R.
Aqueous dispersions of oxygen nanobubbles for potential application in inhalation therapy
title Aqueous dispersions of oxygen nanobubbles for potential application in inhalation therapy
title_full Aqueous dispersions of oxygen nanobubbles for potential application in inhalation therapy
title_fullStr Aqueous dispersions of oxygen nanobubbles for potential application in inhalation therapy
title_full_unstemmed Aqueous dispersions of oxygen nanobubbles for potential application in inhalation therapy
title_short Aqueous dispersions of oxygen nanobubbles for potential application in inhalation therapy
title_sort aqueous dispersions of oxygen nanobubbles for potential application in inhalation therapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9302230/
https://www.ncbi.nlm.nih.gov/pubmed/35864438
http://dx.doi.org/10.1038/s41598-022-16720-3
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