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Serum tumor markers level and their predictive values for solid and micropapillary components in lung adenocarcinoma
BACKGROUND: This study aims to reveal the serum tumor marker (STM) levels in lung adenocarcinoma (LUAD) histological subtypes and evaluate their values in predicting the solid and micropapillary components (SMC). METHODS: We retrospectively analyzed 3100 invasive LUAD patients between January 2017 a...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9302275/ https://www.ncbi.nlm.nih.gov/pubmed/35289087 http://dx.doi.org/10.1002/cam4.4645 |
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author | Li, Zhihua Wu, Weibing Pan, Xianglong Li, Fang Zhu, Quan He, Zhicheng Chen, Liang |
author_facet | Li, Zhihua Wu, Weibing Pan, Xianglong Li, Fang Zhu, Quan He, Zhicheng Chen, Liang |
author_sort | Li, Zhihua |
collection | PubMed |
description | BACKGROUND: This study aims to reveal the serum tumor marker (STM) levels in lung adenocarcinoma (LUAD) histological subtypes and evaluate their values in predicting the solid and micropapillary components (SMC). METHODS: We retrospectively analyzed 3100 invasive LUAD patients between January 2017 and December 2020. Associations between preoperative STMs (CEA, CYFRA21‐1, CA199, CA724, NSE, AFP) and LUAD subtypes were evaluated. Multivariate regression analyses were used to determine the independent predictors. Predictive models for SMC were constructed and AUC (area under the curve) was calculated. RESULTS: CEA and CYFRA21‐1 levels differed across the LUAD histological subtypes, with the SPA (solid‐predominant adenocarcinoma) having the highest level and the LPA (lepidic‐predominant adenocarcinoma) harboring the lowest level (p <0.001). Tumors with SMC also had higher CEA and CYFRA21‐1 levels than those absence of SMC. Gender, tumor size, CEA, Ki‐67, EGFR mutation (solid components only), and tumor differentiation were significantly independently associated with the containing of SMC. Patients were split into two data sets (training set: 2017–2019 and validation set: 2020). The model with gender and tumor size yielded an AUC of 0.723 (training set) and 0.704 (validation set) for the solid component. Combination of CEA, gender, and tumor size led to a significant increase in the predictive accuracy (training set: 0.771, p = 0.009; validation set: 0.747, p = 0.034). The AUC of the model for micropapillary component with only gender and tumor size was 0.699 and 0.711 in the training set and validation set, respectively. Integration of CEA with gender and tumor size significantly improved the predictive performance with an AUC of 0.746 (training set, p = 0.045) and 0.753 (validation set, p <0.001). CONCLUSION: Serum CEA and CYFRA21‐1 varied considerably according to LUAD histological subtypes. The combination of serum CEA and other factors showed prominent values in predicting the SMC. |
format | Online Article Text |
id | pubmed-9302275 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93022752022-07-22 Serum tumor markers level and their predictive values for solid and micropapillary components in lung adenocarcinoma Li, Zhihua Wu, Weibing Pan, Xianglong Li, Fang Zhu, Quan He, Zhicheng Chen, Liang Cancer Med RESEARCH ARTICLES BACKGROUND: This study aims to reveal the serum tumor marker (STM) levels in lung adenocarcinoma (LUAD) histological subtypes and evaluate their values in predicting the solid and micropapillary components (SMC). METHODS: We retrospectively analyzed 3100 invasive LUAD patients between January 2017 and December 2020. Associations between preoperative STMs (CEA, CYFRA21‐1, CA199, CA724, NSE, AFP) and LUAD subtypes were evaluated. Multivariate regression analyses were used to determine the independent predictors. Predictive models for SMC were constructed and AUC (area under the curve) was calculated. RESULTS: CEA and CYFRA21‐1 levels differed across the LUAD histological subtypes, with the SPA (solid‐predominant adenocarcinoma) having the highest level and the LPA (lepidic‐predominant adenocarcinoma) harboring the lowest level (p <0.001). Tumors with SMC also had higher CEA and CYFRA21‐1 levels than those absence of SMC. Gender, tumor size, CEA, Ki‐67, EGFR mutation (solid components only), and tumor differentiation were significantly independently associated with the containing of SMC. Patients were split into two data sets (training set: 2017–2019 and validation set: 2020). The model with gender and tumor size yielded an AUC of 0.723 (training set) and 0.704 (validation set) for the solid component. Combination of CEA, gender, and tumor size led to a significant increase in the predictive accuracy (training set: 0.771, p = 0.009; validation set: 0.747, p = 0.034). The AUC of the model for micropapillary component with only gender and tumor size was 0.699 and 0.711 in the training set and validation set, respectively. Integration of CEA with gender and tumor size significantly improved the predictive performance with an AUC of 0.746 (training set, p = 0.045) and 0.753 (validation set, p <0.001). CONCLUSION: Serum CEA and CYFRA21‐1 varied considerably according to LUAD histological subtypes. The combination of serum CEA and other factors showed prominent values in predicting the SMC. John Wiley and Sons Inc. 2022-03-14 /pmc/articles/PMC9302275/ /pubmed/35289087 http://dx.doi.org/10.1002/cam4.4645 Text en © 2022 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | RESEARCH ARTICLES Li, Zhihua Wu, Weibing Pan, Xianglong Li, Fang Zhu, Quan He, Zhicheng Chen, Liang Serum tumor markers level and their predictive values for solid and micropapillary components in lung adenocarcinoma |
title | Serum tumor markers level and their predictive values for solid and micropapillary components in lung adenocarcinoma |
title_full | Serum tumor markers level and their predictive values for solid and micropapillary components in lung adenocarcinoma |
title_fullStr | Serum tumor markers level and their predictive values for solid and micropapillary components in lung adenocarcinoma |
title_full_unstemmed | Serum tumor markers level and their predictive values for solid and micropapillary components in lung adenocarcinoma |
title_short | Serum tumor markers level and their predictive values for solid and micropapillary components in lung adenocarcinoma |
title_sort | serum tumor markers level and their predictive values for solid and micropapillary components in lung adenocarcinoma |
topic | RESEARCH ARTICLES |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9302275/ https://www.ncbi.nlm.nih.gov/pubmed/35289087 http://dx.doi.org/10.1002/cam4.4645 |
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