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P1245 Polymorphic Variants of HSD3B1 Gene Confer Different Outcome in Specific Subgroups of Patients Infected With SARS-CoV-2

Introduction: Severe respiratory syndrome coronavirus 2 (SARS-CoV-2) uses the androgen receptor (AR), through ACE2 receptor and TMPRSS2, to enter nasal and upper airways epithelial cells. Genetic analyses revealed that HSD3B1 P1245C polymorphic variant increases dihydrotestosterone production and up...

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Detalles Bibliográficos
Autores principales:	Epistolio, Samantha, Ramelli, Giulia, Ottaviano, Margaret, Crupi, Emanuele, Marandino, Laura, Biggiogero, Maira, Maida, Pier Andrea, Ruinelli, Lorenzo, Vogl, Ursula, Mangan, Dylan, Pascale, Mariarosa, Cantù, Marco, Ceschi, Alessandro, Bernasconi, Enos, Mazzucchelli, Luca, Catapano, Carlo, Alimonti, Andrea, Garzoni, Christian, Gillessen Sommer, Silke, Stefanini, Federico Mattia, Franzetti-Pellanda, Alessandra, Frattini, Milo, Pereira Mestre, Ricardo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9302441/ https://www.ncbi.nlm.nih.gov/pubmed/35874037 http://dx.doi.org/10.3389/fmed.2021.793728

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