The Extraglycemic Effect of SGLT-2is on Mineral and Bone Metabolism and Bone Fracture

Type 2 diabetes mellitus (T2DM) is a risk factor for osteoporosis. The effects of T2DM and anti-diabetic agents on bone and mineral metabolism have been observed. Sodium–glucose co-transporter 2 inhibitors (SGLT-2is) promote urinary glucose excretion, reduce blood glucose level, and improve the card...

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Autores principales: Dong, Bingzi, Lv, Ruolin, Wang, Jun, Che, Lin, Wang, Zhongchao, Huai, Zhouyang, Wang, Yangang, Xu, Lili
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9302585/
https://www.ncbi.nlm.nih.gov/pubmed/35872985
http://dx.doi.org/10.3389/fendo.2022.918350
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author Dong, Bingzi
Lv, Ruolin
Wang, Jun
Che, Lin
Wang, Zhongchao
Huai, Zhouyang
Wang, Yangang
Xu, Lili
author_facet Dong, Bingzi
Lv, Ruolin
Wang, Jun
Che, Lin
Wang, Zhongchao
Huai, Zhouyang
Wang, Yangang
Xu, Lili
author_sort Dong, Bingzi
collection PubMed
description Type 2 diabetes mellitus (T2DM) is a risk factor for osteoporosis. The effects of T2DM and anti-diabetic agents on bone and mineral metabolism have been observed. Sodium–glucose co-transporter 2 inhibitors (SGLT-2is) promote urinary glucose excretion, reduce blood glucose level, and improve the cardiovascular and diabetic nephropathy outcomes. In this review, we focused on the extraglycemic effect and physiological regulation of SGLT-2is on bone and mineral metabolism. SGLT-2is affect the bone turnover, microarchitecture, and bone strength indirectly. Clinical evidence of a meta-analysis showed that SGLT-2is might not increase the risk of bone fracture. The effect of SGLT-2is on bone fracture is controversial, and further investigation from a real-world study is needed. Based on its significant benefit on cardiovascular and chronic kidney disease (CKD) outcomes, SGLT-2is are an outstanding choice. Bone mineral density (BMD) and fracture risk evaluation should be considered for patients with a high risk of bone fracture.
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spelling pubmed-93025852022-07-22 The Extraglycemic Effect of SGLT-2is on Mineral and Bone Metabolism and Bone Fracture Dong, Bingzi Lv, Ruolin Wang, Jun Che, Lin Wang, Zhongchao Huai, Zhouyang Wang, Yangang Xu, Lili Front Endocrinol (Lausanne) Endocrinology Type 2 diabetes mellitus (T2DM) is a risk factor for osteoporosis. The effects of T2DM and anti-diabetic agents on bone and mineral metabolism have been observed. Sodium–glucose co-transporter 2 inhibitors (SGLT-2is) promote urinary glucose excretion, reduce blood glucose level, and improve the cardiovascular and diabetic nephropathy outcomes. In this review, we focused on the extraglycemic effect and physiological regulation of SGLT-2is on bone and mineral metabolism. SGLT-2is affect the bone turnover, microarchitecture, and bone strength indirectly. Clinical evidence of a meta-analysis showed that SGLT-2is might not increase the risk of bone fracture. The effect of SGLT-2is on bone fracture is controversial, and further investigation from a real-world study is needed. Based on its significant benefit on cardiovascular and chronic kidney disease (CKD) outcomes, SGLT-2is are an outstanding choice. Bone mineral density (BMD) and fracture risk evaluation should be considered for patients with a high risk of bone fracture. Frontiers Media S.A. 2022-07-07 /pmc/articles/PMC9302585/ /pubmed/35872985 http://dx.doi.org/10.3389/fendo.2022.918350 Text en Copyright © 2022 Dong, Lv, Wang, Che, Wang, Huai, Wang and Xu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Dong, Bingzi
Lv, Ruolin
Wang, Jun
Che, Lin
Wang, Zhongchao
Huai, Zhouyang
Wang, Yangang
Xu, Lili
The Extraglycemic Effect of SGLT-2is on Mineral and Bone Metabolism and Bone Fracture
title The Extraglycemic Effect of SGLT-2is on Mineral and Bone Metabolism and Bone Fracture
title_full The Extraglycemic Effect of SGLT-2is on Mineral and Bone Metabolism and Bone Fracture
title_fullStr The Extraglycemic Effect of SGLT-2is on Mineral and Bone Metabolism and Bone Fracture
title_full_unstemmed The Extraglycemic Effect of SGLT-2is on Mineral and Bone Metabolism and Bone Fracture
title_short The Extraglycemic Effect of SGLT-2is on Mineral and Bone Metabolism and Bone Fracture
title_sort extraglycemic effect of sglt-2is on mineral and bone metabolism and bone fracture
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9302585/
https://www.ncbi.nlm.nih.gov/pubmed/35872985
http://dx.doi.org/10.3389/fendo.2022.918350
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