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If amyloid drives Alzheimer disease, why have anti-amyloid therapies not yet slowed cognitive decline?
Strong genetic evidence supports an imbalance between production and clearance of amyloid β-protein (Aβ) in people with Alzheimer disease (AD). Microglia that are potentially involved in alternative mechanisms are actually integral to the amyloid cascade. Fluid biomarkers and brain imaging place acc...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9302755/ https://www.ncbi.nlm.nih.gov/pubmed/35862308 http://dx.doi.org/10.1371/journal.pbio.3001694 |