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Targeted Antimicrobial Agents as Potential Tools for Modulating the Gut Microbiome
The gut microbiome plays a pivotal role in maintaining the health of the hosts; however, there is accumulating evidence that certain bacteria in the host, termed pathobionts, play roles in the progression of diseases. Although antibiotics can be used to eradicate unwanted bacteria, the side effects...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9302920/ https://www.ncbi.nlm.nih.gov/pubmed/35875544 http://dx.doi.org/10.3389/fmicb.2022.879207 |
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author | Chou, Shuli Zhang, Shiqing Guo, Huating Chang, Yung-fu Zhao, Wenjing Mou, Xiangyu |
author_facet | Chou, Shuli Zhang, Shiqing Guo, Huating Chang, Yung-fu Zhao, Wenjing Mou, Xiangyu |
author_sort | Chou, Shuli |
collection | PubMed |
description | The gut microbiome plays a pivotal role in maintaining the health of the hosts; however, there is accumulating evidence that certain bacteria in the host, termed pathobionts, play roles in the progression of diseases. Although antibiotics can be used to eradicate unwanted bacteria, the side effects of antibiotic treatment lead to a great need for more targeted antimicrobial agents as tools to modulate the microbiome more precisely. Herein, we reviewed narrow-spectrum antibiotics naturally made by plants and microorganisms, followed by more targeted antibiotic agents including synthetic peptides, phage, and targeted drug delivery systems, from the perspective of using them as potential tools for modulating the gut microbiome for favorable effects on the health of the host. Given the emerging discoveries on pathobionts and the increasing knowledge on targeted antimicrobial agents reviewed in this article, we anticipate targeted antimicrobial agents will emerge as a new generation of a drug to treat microbiome-involved diseases. |
format | Online Article Text |
id | pubmed-9302920 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93029202022-07-22 Targeted Antimicrobial Agents as Potential Tools for Modulating the Gut Microbiome Chou, Shuli Zhang, Shiqing Guo, Huating Chang, Yung-fu Zhao, Wenjing Mou, Xiangyu Front Microbiol Microbiology The gut microbiome plays a pivotal role in maintaining the health of the hosts; however, there is accumulating evidence that certain bacteria in the host, termed pathobionts, play roles in the progression of diseases. Although antibiotics can be used to eradicate unwanted bacteria, the side effects of antibiotic treatment lead to a great need for more targeted antimicrobial agents as tools to modulate the microbiome more precisely. Herein, we reviewed narrow-spectrum antibiotics naturally made by plants and microorganisms, followed by more targeted antibiotic agents including synthetic peptides, phage, and targeted drug delivery systems, from the perspective of using them as potential tools for modulating the gut microbiome for favorable effects on the health of the host. Given the emerging discoveries on pathobionts and the increasing knowledge on targeted antimicrobial agents reviewed in this article, we anticipate targeted antimicrobial agents will emerge as a new generation of a drug to treat microbiome-involved diseases. Frontiers Media S.A. 2022-07-07 /pmc/articles/PMC9302920/ /pubmed/35875544 http://dx.doi.org/10.3389/fmicb.2022.879207 Text en Copyright © 2022 Chou, Zhang, Guo, Chang, Zhao and Mou. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Chou, Shuli Zhang, Shiqing Guo, Huating Chang, Yung-fu Zhao, Wenjing Mou, Xiangyu Targeted Antimicrobial Agents as Potential Tools for Modulating the Gut Microbiome |
title | Targeted Antimicrobial Agents as Potential Tools for Modulating the Gut Microbiome |
title_full | Targeted Antimicrobial Agents as Potential Tools for Modulating the Gut Microbiome |
title_fullStr | Targeted Antimicrobial Agents as Potential Tools for Modulating the Gut Microbiome |
title_full_unstemmed | Targeted Antimicrobial Agents as Potential Tools for Modulating the Gut Microbiome |
title_short | Targeted Antimicrobial Agents as Potential Tools for Modulating the Gut Microbiome |
title_sort | targeted antimicrobial agents as potential tools for modulating the gut microbiome |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9302920/ https://www.ncbi.nlm.nih.gov/pubmed/35875544 http://dx.doi.org/10.3389/fmicb.2022.879207 |
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