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Technical note: Validation of an ultrahigh dose rate pulsed electron beam monitoring system using a current transformer for FLASH preclinical studies
PURPOSE: The Oriatron eRT6 is a linear accelerator (linac) used in FLASH preclinical studies able to reach dose rates ranging from conventional (CONV) up to ultrahigh (UHDR). This work describes the implementation of commercially available beam current transformers (BCTs) as online monitoring tools...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303205/ https://www.ncbi.nlm.nih.gov/pubmed/35066878 http://dx.doi.org/10.1002/mp.15474 |
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author | Gonçalves Jorge, Patrik Grilj, Veljko Bourhis, Jean Vozenin, Marie‐Catherine Germond, Jean‐François Bochud, François Bailat, Claude Moeckli, Raphaël |
author_facet | Gonçalves Jorge, Patrik Grilj, Veljko Bourhis, Jean Vozenin, Marie‐Catherine Germond, Jean‐François Bochud, François Bailat, Claude Moeckli, Raphaël |
author_sort | Gonçalves Jorge, Patrik |
collection | PubMed |
description | PURPOSE: The Oriatron eRT6 is a linear accelerator (linac) used in FLASH preclinical studies able to reach dose rates ranging from conventional (CONV) up to ultrahigh (UHDR). This work describes the implementation of commercially available beam current transformers (BCTs) as online monitoring tools compatible with CONV and UHDR irradiations for preclinical FLASH studies. METHODS: Two BCTs were used to measure the output of the Oriatron eRT6 linac. First, the correspondence between the set nominal beam parameters and those measured by the BCTs was checked. Then, we established the relationship between the total exit charge (measured by BCTs) and the absorbed dose to water. The influence of the pulse width (PW) and the pulse repetition frequency (PRF) at UHDR was characterized, as well as the short‐ and long‐term stabilities of the relationship between the exit charge and the dose at CONV and UHDR. RESULTS: The BCTs were able to determine consistently the number of pulses, PW, and PRF. For fixed PW and pulse height, the exit charge measured from BCTs was correlated with the dose, and linear relationships were found with uncertainties of 0.5 % and 3 % in CONV and UHDR mode, respectively. Short‐ and long‐term stabilities of the dose‐to‐charge ratio were below 1.6 %. CONCLUSIONS: We implemented commercially available BCTs and demonstrated their ability to act as online beam monitoring systems to support FLASH preclinical studies with CONV and UHDR irradiations. The implemented BCTs support dosimetric measurements, highlight variations among multiple measurements in a row, enable monitoring of the physics parameters used for irradiation, and are an important step for the safety of the clinical translation of FLASH radiation therapy. |
format | Online Article Text |
id | pubmed-9303205 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93032052022-07-22 Technical note: Validation of an ultrahigh dose rate pulsed electron beam monitoring system using a current transformer for FLASH preclinical studies Gonçalves Jorge, Patrik Grilj, Veljko Bourhis, Jean Vozenin, Marie‐Catherine Germond, Jean‐François Bochud, François Bailat, Claude Moeckli, Raphaël Med Phys EMERGING IMAGING AND THERAPY MODALITIES PURPOSE: The Oriatron eRT6 is a linear accelerator (linac) used in FLASH preclinical studies able to reach dose rates ranging from conventional (CONV) up to ultrahigh (UHDR). This work describes the implementation of commercially available beam current transformers (BCTs) as online monitoring tools compatible with CONV and UHDR irradiations for preclinical FLASH studies. METHODS: Two BCTs were used to measure the output of the Oriatron eRT6 linac. First, the correspondence between the set nominal beam parameters and those measured by the BCTs was checked. Then, we established the relationship between the total exit charge (measured by BCTs) and the absorbed dose to water. The influence of the pulse width (PW) and the pulse repetition frequency (PRF) at UHDR was characterized, as well as the short‐ and long‐term stabilities of the relationship between the exit charge and the dose at CONV and UHDR. RESULTS: The BCTs were able to determine consistently the number of pulses, PW, and PRF. For fixed PW and pulse height, the exit charge measured from BCTs was correlated with the dose, and linear relationships were found with uncertainties of 0.5 % and 3 % in CONV and UHDR mode, respectively. Short‐ and long‐term stabilities of the dose‐to‐charge ratio were below 1.6 %. CONCLUSIONS: We implemented commercially available BCTs and demonstrated their ability to act as online beam monitoring systems to support FLASH preclinical studies with CONV and UHDR irradiations. The implemented BCTs support dosimetric measurements, highlight variations among multiple measurements in a row, enable monitoring of the physics parameters used for irradiation, and are an important step for the safety of the clinical translation of FLASH radiation therapy. John Wiley and Sons Inc. 2022-02-07 2022-03 /pmc/articles/PMC9303205/ /pubmed/35066878 http://dx.doi.org/10.1002/mp.15474 Text en © 2022 The Authors. Medical Physics published by Wiley Periodicals LLC on behalf of American Association of Physicists in Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | EMERGING IMAGING AND THERAPY MODALITIES Gonçalves Jorge, Patrik Grilj, Veljko Bourhis, Jean Vozenin, Marie‐Catherine Germond, Jean‐François Bochud, François Bailat, Claude Moeckli, Raphaël Technical note: Validation of an ultrahigh dose rate pulsed electron beam monitoring system using a current transformer for FLASH preclinical studies |
title | Technical note: Validation of an ultrahigh dose rate pulsed electron beam monitoring system using a current transformer for FLASH preclinical studies |
title_full | Technical note: Validation of an ultrahigh dose rate pulsed electron beam monitoring system using a current transformer for FLASH preclinical studies |
title_fullStr | Technical note: Validation of an ultrahigh dose rate pulsed electron beam monitoring system using a current transformer for FLASH preclinical studies |
title_full_unstemmed | Technical note: Validation of an ultrahigh dose rate pulsed electron beam monitoring system using a current transformer for FLASH preclinical studies |
title_short | Technical note: Validation of an ultrahigh dose rate pulsed electron beam monitoring system using a current transformer for FLASH preclinical studies |
title_sort | technical note: validation of an ultrahigh dose rate pulsed electron beam monitoring system using a current transformer for flash preclinical studies |
topic | EMERGING IMAGING AND THERAPY MODALITIES |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303205/ https://www.ncbi.nlm.nih.gov/pubmed/35066878 http://dx.doi.org/10.1002/mp.15474 |
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