Highly efficient CRISPR-mediated large DNA docking and multiplexed prime editing using a single baculovirus

CRISPR-based precise gene-editing requires simultaneous delivery of multiple components into living cells, rapidly exceeding the cargo capacity of traditional viral vector systems. This challenge represents a major roadblock to genome engineering applications. Here we exploit the unmatched heterolog...

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Detalles Bibliográficos
Autores principales: Aulicino, Francesco, Pelosse, Martin, Toelzer, Christine, Capin, Julien, Ilegems, Erwin, Meysami, Parisa, Rollarson, Ruth, Berggren, Per-Olof, Dillingham, Mark Simon, Schaffitzel, Christiane, Saleem, Moin A, Welsh, Gavin I, Berger, Imre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Synthetic Biology and Bioengineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303279/
https://www.ncbi.nlm.nih.gov/pubmed/35801912
http://dx.doi.org/10.1093/nar/gkac587

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