Short LNA-modified oligonucleotide probes as efficient disruptors of DNA G-quadruplexes

G-quadruplexes (G4s) are well known non-canonical DNA secondary structures that can form in human cells. Most of the tools available to investigate G4-biology rely on small molecule ligands that stabilise these structures. However, the development of probes that disrupt G4s is equally important to s...

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Detalles Bibliográficos
Autores principales: Chowdhury, Souroprobho, Wang, Jiayi, Nuccio, Sabrina Pia, Mao, Hanbin, Di Antonio, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303293/
https://www.ncbi.nlm.nih.gov/pubmed/35801856
http://dx.doi.org/10.1093/nar/gkac569

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