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Loosely-packed dynamical structures with partially-melted surface being the key for thermophilic argonaute proteins achieving high DNA-cleavage activity

Prokaryotic Argonaute proteins (pAgos) widely participate in hosts to defend against the invasion of nucleic acids. Compared with the CRISPR-Cas system, which requires a specific motif on the target and can only use RNA as guide, pAgos exhibit precise endonuclease activity on any arbitrary target se...

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Detalles Bibliográficos
Autores principales:	Zheng, Lirong, Lu, Hui, Zan, Bing, Li, Song, Liu, Hao, Liu, Zhuo, Huang, Juan, Liu, Yongjia, Jiang, Fan, Liu, Qian, Feng, Yan, Hong, Liang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303296/ https://www.ncbi.nlm.nih.gov/pubmed/35766425 http://dx.doi.org/10.1093/nar/gkac565

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