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Characterization of sequence contexts that favor alternative end joining at Cas9-induced double-strand breaks

Alternative end joining (alt-EJ) mechanisms, such as polymerase theta-mediated end joining, are increasingly recognized as important contributors to inaccurate double-strand break repair. We previously proposed an alt-EJ model whereby short DNA repeats near a double-strand break anneal to form secon...

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Detalles Bibliográficos
Autores principales:	Hanscom, Terrence, Woodward, Nicholas, Batorsky, Rebecca, Brown, Alexander J, Roberts, Steven A, McVey, Mitch
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303309/ https://www.ncbi.nlm.nih.gov/pubmed/35819195 http://dx.doi.org/10.1093/nar/gkac575

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