Cargando…

Dissecting the IL‐6 pathway in cardiometabolic disease: A Mendelian randomization study on both IL6 and IL6R

AIMS: Chronic inflammation is a risk factor for cardiovascular disease (CVD). IL‐6 signalling perturbation through IL‐6 or IL‐6R blockade may have potential benefit on cardiovascular risk. It is unknown whether targeting either IL‐6 or IL‐6 receptor may result in similar effects on CVD and adverse e...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cupido, Arjen J., Asselbergs, Folkert W., Natarajan, Pradeep, Ridker, Paul M., Hovingh, G. Kees, Schmidt, A. Floriaan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303316/ https://www.ncbi.nlm.nih.gov/pubmed/34931349 http://dx.doi.org/10.1111/bcp.15191

Ejemplares similares

Low‐Density Lipoprotein Cholesterol Attributable Cardiovascular Disease Risk Is Sex Specific
por: Cupido, Arjen J., et al.
Publicado: (2022)

Genetically Predicted Neutrophil-to-Lymphocyte Ratio and Coronary Artery Disease: Evidence From Mendelian Randomization
por: Cupido, Arjen J., et al.
Publicado: (2022)

Association of Polymorphisms of IL-6 Pathway Genes (IL6, IL6R and IL6ST) with COVID-19 Severity in an Amazonian Population
por: Rodrigues, Fabíola Brasil Barbosa, et al.
Publicado: (2023)

IL6/IL6R genetic diversity and plasma IL6 levels in bipolar disorder: An Indo-French study
por: Sundaresh, Aparna, et al.
Publicado: (2019)

The IL6 Gene Promoter SNP and Plasma IL-6 in Response to Diet Intervention
por: Rana, Brinda K., et al.
Publicado: (2017)

A Potential Role of IL-6/IL-6R in the Development and Management of Colon Cancer
por: Turano, Mimmo, et al.
Publicado: (2021)

Discovery and characterization of a monoclonal antibody targeting a conformational epitope of IL-6/IL-6Rα to inhibit IL-6/ IL-6Rα/gp130 hexameric signaling complex formation
por: Chou, Chun-Chi, et al.
Publicado: (2022)

IL-6 Trans-Signaling via the Soluble IL-6 Receptor: Importance for the Pro-Inflammatory Activities of IL-6
por: Rose-John, Stefan
Publicado: (2012)

Classical Signaling and Trans-Signaling Pathways Stimulated by Megalobrama amblycephala IL-6 and IL-6R
por: Wang, Jixiu, et al.
Publicado: (2022)

Genetic IL-6R variants and therapeutic inhibition of IL-6 receptor signalling in COVID-19
por: Garbers, Christoph, et al.
Publicado: (2021)

IL-6 Quotient (The Ratio of Cerebrospinal Fluid IL-6 to Serum IL-6) as a Biomarker of an Unruptured Intracranial Aneurysm
por: Kamińska, Joanna, et al.
Publicado: (2021)

The function of the soluble interleukin 6 (IL-6) receptor in vivo: sensitization of human soluble IL-6 receptor transgenic mice towards IL- 6 and prolongation of the plasma half-life of IL-6
Publicado: (1996)

New tale on LianHuaQingWen: IL6R/IL6/IL6ST complex is a potential target for COVID-19 treatment
por: Tianyu, Zhao, et al.
Publicado: (2021)

Pathogenic roles of IL-6 and IL-6 blocking therapy on rheumatoid arthritis
por: Yoshizaki, K, et al.
Publicado: (2003)

Higher IL-6 and IL6:IGF Ratio in Patients with Barth Syndrome
por: Wilson, Lori D, et al.
Publicado: (2012)

Athletic humans and horses: Comparative analysis of interleukin-6 (IL-6) and IL-6 receptor (IL-6R) expression in peripheral blood mononuclear cells in trained and untrained subjects at rest
por: Capomaccio, Stefano, et al.
Publicado: (2011)

Differential expression of IL-6/IL-6R and MAO-A regulates invasion/angiogenesis in breast cancer
por: Bharti, Rashmi, et al.
Publicado: (2018)

Association between the expression levels of IL-6 and IL-6R in the hepatocellular carcinoma microenvironment and postoperative recurrence
por: Zhang, Mao, et al.
Publicado: (2018)

Potential therapeutic implications of IL-6/IL-6R/gp130-targeting agents in breast cancer
por: Heo, Tae-Hwe, et al.
Publicado: (2016)

Is IL-6 both a cytokine and a neurotrophic factor?
Publicado: (1996)

Assessment of Interleukins IL-4, IL-6, IL-8, IL-10 in Acute Urticaria
por: Papadopoulos, Jordan, et al.
Publicado: (2014)

A study of genes encoding cytokines (IL6, IL10, TNF), cytokine receptors (IL6R, IL6ST), and glucocorticoid receptor (NR3C1) and susceptibility to bronchopulmonary dysplasia
por: Huusko, Johanna M, et al.
Publicado: (2014)

Dual STAT-3 and IL-6R inhibition with stattic and tocilizumab decreases migration, invasion and proliferation of prostate cancer cells by targeting the IL-6/IL-6R/STAT-3 axis
por: Méndez-Clemente, Anibal, et al.
Publicado: (2022)

Extramedullary Expansion of Hematopoietic Progenitor Cells in Interleukin (IL)-6–sIL-6R Double Transgenic Mice
por: Peters, Malte, et al.
Publicado: (1997)

123 Serum IL6 and Soluble IL6R Are Correlated With Lung Function in Non-Hispanic Whites with Asthma
por: Hawkins, Gregory, et al.
Publicado: (2012)

Genetic IL-6R variants and therapeutic inhibition of IL-6 receptor signalling in COVID-19 – Authors' reply
por: Bovijn, Jonas, et al.
Publicado: (2021)

Kynurenine metabolites predict survival in pulmonary arterial hypertension: A role for IL-6/IL-6Rα
por: Cai, Zongye, et al.
Publicado: (2022)

Serum miR-17, IL-4, and IL-6 levels for diagnosis of endometriosis
por: Wang, Fang, et al.
Publicado: (2018)

Special issue on Interleukin-6 (IL-6)
por: Rincon, Mercedes
Publicado: (2012)

Ga(III) Nanoparticles Inhibit Growth of both Mycobacterium tuberculosis and HIV and Release of Interleukin-6 (IL-6) and IL-8 in Coinfected Macrophages
por: Choi, Seoung-ryoung, et al.
Publicado: (2017)

Inhibition of IL-6+IL-6 soluble receptor-stimulated aromatase activity by the IL-6 antagonist, Sant 7, in breast tissue-derived fibroblasts
por: Purohit, A, et al.
Publicado: (2003)

Cathepsin S provokes interleukin-6 (IL-6) trans-signaling through cleavage of the IL-6 receptor in vitro
por: Flynn, Charlotte M., et al.
Publicado: (2020)

Associations of genetically predicted IL-6 signaling with cardiovascular disease risk across population subgroups
por: Georgakis, Marios K., et al.
Publicado: (2022)

The nature of human IL-6
por: Puel, Anne, et al.
Publicado: (2019)

IL-1beta, IL-6 and IL-8 levels in gyneco-obstetric infections.
por: Basso, Beatriz, et al.
Publicado: (2005)

Circulating IL-6, IL-10, and TNF-alpha and IL-10/IL-6 and IL-10/TNF-alpha ratio profiles of polyparasitized individuals in rural and urban areas of gabon
por: M’Bondoukwé, Noé Patrick, et al.
Publicado: (2022)

IL-6 pathway-driven investigation of response to IL-6 receptor inhibition in rheumatoid arthritis
por: Wang, Jianmei, et al.
Publicado: (2013)

Targeting IL-6 Trans-Signaling: Amplifying the Benefits of IL-6 Inhibition in Myocardial Infarction
por: Aukrust, Pål, et al.
Publicado: (2021)

Obesity Is a Positive Modulator of IL-6R and IL-6 Expression in the Subcutaneous Adipose Tissue: Significance for Metabolic Inflammation
por: Sindhu, Sardar, et al.
Publicado: (2015)

Increased levels of IL-6, sIL-6R, and sgp130 in the aqueous humor and serum of patients with diabetic retinopathy
por: Chen, Hui, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_b987d8vn9go0ila2qb5kl6ai7h