Cryo neutron crystallography demonstrates influence of RNA 2′-OH orientation on conformation, sugar pucker and water structure

The ribose 2′-hydroxyl is the key chemical difference between RNA and DNA and primary source of their divergent structural and functional characteristics. Macromolecular X-ray diffraction experiments typically do not reveal the positions of hydrogen atoms. Thus, standard crystallography cannot deter...

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Detalles Bibliográficos
Autores principales: Harp, Joel M, Lybrand, Terry P, Pallan, Pradeep S, Coates, Leighton, Sullivan, Brendan, Egli, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303348/
https://www.ncbi.nlm.nih.gov/pubmed/35819202
http://dx.doi.org/10.1093/nar/gkac577

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