Plasma concentrations of methylphenidate enantiomers in adults with ADHD and substance use disorder, with focus on high doses and relationship to carboxylesterase activity

Scarce data are available on methylphenidate (MPH) plasma concentrations reached after doses higher than 180 mg. The interindividual and intraindividual variability in the exposure of MPH and ritalinic acid (RA) enantiomers was examined in 28 patients with ADHD and substance use disorders, with MPH...

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Detalles Bibliográficos
Autores principales: Arvidsson, Michel, Franck, Johan, Ackehed, Gerd, Pettersson Bergstrand, Madeleine, Ekström, Lena, Rosenborg, Staffan, Dahl, Marja‐Liisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Clinical Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303366/
https://www.ncbi.nlm.nih.gov/pubmed/35040257
http://dx.doi.org/10.1111/bcpt.13707

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