Selective pericentromeric heterochromatin dismantling caused by TP53 activation during senescence

Cellular senescence triggers various types of heterochromatin remodeling that contribute to aging. However, the age-related mechanisms that lead to these epigenetic alterations remain elusive. Here, we asked how two key aging hallmarks, telomere shortening and constitutive heterochromatin loss, are...

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Detalles Bibliográficos
Autores principales: Mendez-Bermudez, Aaron, Lototska, Liudmyla, Pousse, Melanie, Tessier, Florent, Croce, Oliver, Latrick, Chrysa M, Cherdyntseva, Veronica, Nassour, Joe, Xiaohua, Jiang, Lu, Yiming, Abbadie, Corinne, Gagos, Sarantis, Ye, Jing, Gilson, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303393/
https://www.ncbi.nlm.nih.gov/pubmed/35819196
http://dx.doi.org/10.1093/nar/gkac603

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303393/
https://www.ncbi.nlm.nih.gov/pubmed/35819196
http://dx.doi.org/10.1093/nar/gkac603

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