Cargando…

Transcranial magnetic stimulation as biomarker of excitability in drug development: A randomized, double‐blind, placebo‐controlled, cross‐over study

AIMS: The purpose of this study was to investigate pharmacodynamic effects of drugs targeting cortical excitability using transcranial magnetic stimulation (TMS) combined with electromyography (EMG) and electroencephalography (EEG) in healthy subjects, to further develop TMS outcomes as biomarkers f...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ruijs, Titia Q., Heuberger, Jules A. A. C., de Goede, Annika A., Ziagkos, Dimitrios, Otto, Marije E., Doll, Robert J., van Putten, Michel J. A. M., Groeneveld, Geert Jan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303426/ https://www.ncbi.nlm.nih.gov/pubmed/35028950 http://dx.doi.org/10.1111/bcp.15232

Ejemplares similares

Effects of Mexiletine and Lacosamide on Nerve Excitability in Healthy Subjects: A Randomized, Double‐Blind, Placebo‐Controlled, Crossover Study
por: Ruijs, Titia Q., et al.
Publicado: (2022)

Muscle velocity recovery cycles as pharmacodynamic biomarker: Effects of mexiletine in a randomized double‐blind placebo‐controlled cross‐over study
por: Ruijs, Titia Q., et al.
Publicado: (2022)

Transcranial magnetic stimulation as a translational biomarker for AMPA receptor modulation
por: O’Donnell, Patricio, et al.
Publicado: (2021)

Machine Learning Techniques for Developing Remotely Monitored Central Nervous System Biomarkers Using Wearable Sensors: A Narrative Literature Review
por: ZhuParris, Ahnjili, et al.
Publicado: (2023)

Targeting for Success: Demonstrating Proof-of-Concept with Mechanistic Early Phase Clinical Pharmacology Studies for Disease-Modification in Neurodegenerative Disorders
por: Vissers, Maurits F. J. M., et al.
Publicado: (2021)

Quantification of tremor using consumer product accelerometry is feasible in patients with essential tremor and Parkinson’s disease: a comparative study
por: van Brummelen, Emilie M. J., et al.
Publicado: (2020)

Pharmacokinetic Modeling and Dose Selection in a Randomized, Double-Blind, Placebo-Controlled Trial of a Human Recombinant Alkaline Phosphatase in Healthy Volunteers
por: Peters, Esther, et al.
Publicado: (2016)

Effect of sustained high buprenorphine plasma concentrations on fentanyl-induced respiratory depression: A placebo-controlled crossover study in healthy volunteers and opioid-tolerant patients
por: Moss, Laurence M., et al.
Publicado: (2022)

Repeatability of long intracortical inhibition in healthy subjects
por: de Goede, Annika A., et al.
Publicado: (2016)

A Placebo‐Controlled Study to Assess the Sensitivity of Finger Tapping to Medication Effects in Parkinson's Disease
por: Thijssen, Eva, et al.
Publicado: (2022)

Treatment of internuclear ophthalmoparesis in multiple sclerosis with fampridine: A randomized double‐blind, placebo‐controlled cross‐over trial
por: Kanhai, Kawita M. S., et al.
Publicado: (2019)

Effect of different pulse numbers of transcranial magnetic stimulation on motor cortex excitability: Single‐blind, randomized cross‐over design
por: Tang, Zhi‐Ming, et al.
Publicado: (2019)

Good Clinical Trials by removing defensive interpretation of Good Clinical Practice guidelines
por: den Heijer, Jonas M., et al.
Publicado: (2021)

A leucine‐rich repeat kinase 2 (LRRK2) pathway biomarker characterization study in patients with Parkinson's disease with and without LRRK2 mutations and healthy controls
por: Vissers, Maurits F. J. M., et al.
Publicado: (2023)

Spatiotemporal Dynamics of Single and Paired Pulse TMS-EEG Responses
por: de Goede, Annika A., et al.
Publicado: (2020)

Additive effect of erythropoietin use on exercise-induced endothelial activation and hypercoagulability in athletes
por: Heuberger, Jules A. A. C., et al.
Publicado: (2020)

Resting Motor Threshold, MEP and TEP Variability During Daytime
por: ter Braack, Esther M., et al.
Publicado: (2018)

Accurate Coil Positioning is Important for Single and Paired Pulse TMS on the Subject Level
por: de Goede, Annika A., et al.
Publicado: (2018)

Repetitive Transcranial Magnetic Stimulation in the Treatment of depression: A Randomized, Double-blind, Placebo-controlled Trial
por: Lingeswaran, Anand
Publicado: (2011)

Conducting double-blind placebo-controlled clinical trials of transcranial alternating current stimulation (tACS)
por: Frohlich, Flavio, et al.
Publicado: (2021)

Safety, pharmacokinetics and target engagement of novel RIPK1 inhibitor SAR443060 (DNL747) for neurodegenerative disorders: Randomized, placebo‐controlled, double‐blind phase I/Ib studies in healthy subjects and patients
por: Vissers, Maurits F. J. M., et al.
Publicado: (2022)

Acute retigabine‐induced effects on myelinated motor axons in amyotrophic lateral sclerosis
por: Sleutjes, Boudewijn T. H. M., et al.
Publicado: (2022)

A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Crossover Study to Evaluate the Pharmacodynamic Effects of VX-150, a Highly Selective Na(V)1.8 Inhibitor, in Healthy Male Adults
por: Hijma, Hemme J, et al.
Publicado: (2021)

Tracking cortical excitability dynamics with transcranial magnetic stimulation in focal epilepsy
por: Helling, Robert M., et al.
Publicado: (2022)

Transcranial magnetic stimulation tracks subminute changes in cortical excitability during propofol anesthesia
por: Gersner, Roman, et al.
Publicado: (2020)

Volitional muscle activity paired with transcranial magnetic stimulation increases corticospinal excitability
por: Edwardson, Matthew A., et al.
Publicado: (2015)

A phase I, randomized, double‐blind, placebo‐controlled, single‐ and multiple dose escalation study evaluating the safety, pharmacokinetics and pharmacodynamics of VX‐128, a highly selective Na(v)1.8 inhibitor, in healthy adults
por: Hijma, Hemme J., et al.
Publicado: (2021)

Repetitive Transcranial Magnetic Stimulation With H-Coil in Alzheimer's Disease: A Double-Blind, Placebo-Controlled Pilot Study
por: Leocani, Letizia, et al.
Publicado: (2021)

Tolerance to Opioid‐Induced Respiratory Depression in Chronic High‐Dose Opioid Users: A Model‐Based Comparison With Opioid‐Naïve Individuals
por: Algera, Marijke Hyke, et al.
Publicado: (2020)

Transcranial Magnetic Stimulation for the treatment of tinnitus: Effects on cortical excitability
por: Langguth, Berthold, et al.
Publicado: (2007)

No Modulation of Visual Cortex Excitability by Transcranial Direct Current Stimulation
por: Brückner, Sabrina, et al.
Publicado: (2016)

Effects of Transcranial Ultrasound Stimulation on Trigeminal Blink Reflex Excitability
por: Guerra, Andrea, et al.
Publicado: (2021)

Low-intensity transcranial ultrasound stimulation facilitates hand motor function and cortical excitability: A crossover, randomized, double blind study
por: Zhang, Meng-Fei, et al.
Publicado: (2022)

Anodal Transcranial Direct Current Stimulation over the Vertex Enhances Leg Motor Cortex Excitability Bilaterally
por: Ghosh, Soumya, et al.
Publicado: (2019)

Transcranial static magnetic stimulation over the motor cortex can facilitate the contralateral cortical excitability in human
por: Takamatsu, Yasuyuki, et al.
Publicado: (2021)

Transcranial pulsed electromagnetic fields for multiple chemical sensitivity: study protocol for a randomized, double-blind, placebo-controlled trial
por: Tran, Marie Thi Dao, et al.
Publicado: (2013)

Review of WADA Prohibited Substances: Limited Evidence for Performance-Enhancing Effects
por: Heuberger, Jules A. A. C., et al.
Publicado: (2018)

Effects of Slow Oscillatory Transcranial Alternating Current Stimulation on Motor Cortical Excitability Assessed by Transcranial Magnetic Stimulation
por: Geffen, Asher, et al.
Publicado: (2021)

Mitochondrial function, grip strength, and activity are related to recovery of mobility after a total knee arthroplasty
por: van Diemen, Marcus P. J., et al.
Publicado: (2022)

Combined transcranial magnetic stimulation and electroencephalography reveals alterations in cortical excitability during pain
por: Chowdhury, Nahian Shahmat, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_jsnmbr8h5snq5no907e955i9qd