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Structural Basis for Chaperone‐Independent Ubiquitination of Tau Protein by Its E3 Ligase CHIP

The multi‐site ubiquitination of Tau protein found in Alzheimer's disease filaments hints at the failed attempt of neurons to remove early toxic species. The ubiquitin‐dependent degradation of Tau is regulated in vivo by the E3 ligase CHIP, a quality controller of the cell proteome dedicated to...

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Detalles Bibliográficos
Autores principales:	Munari, Francesca, Mollica, Luca, Valente, Carlo, Parolini, Francesca, Kachoie, Elham Ataie, Arrigoni, Giorgio, D'Onofrio, Mariapina, Capaldi, Stefano, Assfalg, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303552/ https://www.ncbi.nlm.nih.gov/pubmed/35107860 http://dx.doi.org/10.1002/anie.202112374

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