Astrocyte‐targeting RNA interference against mutated superoxide dismutase 1 induces motoneuron plasticity and protects fast‐fatigable motor units in a mouse model of amyotrophic lateral sclerosis

In amyotrophic lateral sclerosis (ALS) caused by SOD1 gene mutations, both cell‐autonomous and noncell‐autonomous mechanisms lead to the selective degeneration of motoneurons (MN). Here, we evaluate the therapeutic potential of gene therapy targeting mutated SOD1 in mature astrocytes using mice expr...

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Detalles Bibliográficos
Autores principales: Rochat, Cylia, Bernard‐Marissal, Nathalie, Källstig, Emma, Pradervand, Sylvain, Perrin, Florence E., Aebischer, Patrick, Raoul, Cédric, Schneider, Bernard L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303637/
https://www.ncbi.nlm.nih.gov/pubmed/34978340
http://dx.doi.org/10.1002/glia.24140

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