Role of air pollutants mediated oxidative stress in respiratory diseases

Airborne particulate (PM) components from fossil fuel combustion can induce oxidative stress initiated by reactive oxygen species (ROS) that are strongly correlated with airway inflammation and asthma. A valid biomarker of airway inflammation is fractionated exhaled nitric oxide (FENO). The oxidativ...

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Detalles Bibliográficos
Autores principales: Traina, Giovanni, Bolzacchini, Ezio, Bonini, Maira, Contini, Daniele, Mantecca, Paride, Caimmi, Silvia Maria Elena, Licari, Amelia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Special Issue: 2021 Update From The Italian Society Of Pediatric Allergy And Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303668/
https://www.ncbi.nlm.nih.gov/pubmed/35080317
http://dx.doi.org/10.1111/pai.13625
Descripción
Sumario:Airborne particulate (PM) components from fossil fuel combustion can induce oxidative stress initiated by reactive oxygen species (ROS) that are strongly correlated with airway inflammation and asthma. A valid biomarker of airway inflammation is fractionated exhaled nitric oxide (FENO). The oxidative potential of PM2.5 can be evaluated with the dithiothreitol (DTT) dosage, which represents both ROS chemically produced and intracellular ROS of macrophages. This correlates with quality indicators of the internal environment and ventilation strategies such as dilution and removal of airborne contaminants.

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