Cargando…

Kangaroo mother care had a protective effect on the volume of brain structures in young adults born preterm

AIM: The protective effects of Kangaroo mother care (KMC) on the neurodevelopment of preterm infants are well established, but we do not know whether the benefits persist beyond infancy. Our aim was to determine whether providing KMC in infancy affected brain volumes in young adulthood. METHOD: Stan...

Descripción completa

Detalles Bibliográficos
Autores principales: Charpak, Nathalie, Tessier, Rejean, Ruiz, Juan Gabriel, Uriza, Felipe, Hernandez, José Tiberio, Cortes, Darwin, Montealegre‐Pomar, Adriana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303677/
https://www.ncbi.nlm.nih.gov/pubmed/35067976
http://dx.doi.org/10.1111/apa.16265
_version_ 1784751926272851968
author Charpak, Nathalie
Tessier, Rejean
Ruiz, Juan Gabriel
Uriza, Felipe
Hernandez, José Tiberio
Cortes, Darwin
Montealegre‐Pomar, Adriana
author_facet Charpak, Nathalie
Tessier, Rejean
Ruiz, Juan Gabriel
Uriza, Felipe
Hernandez, José Tiberio
Cortes, Darwin
Montealegre‐Pomar, Adriana
author_sort Charpak, Nathalie
collection PubMed
description AIM: The protective effects of Kangaroo mother care (KMC) on the neurodevelopment of preterm infants are well established, but we do not know whether the benefits persist beyond infancy. Our aim was to determine whether providing KMC in infancy affected brain volumes in young adulthood. METHOD: Standardised cognitive, memory and motor skills tests were used to determine the brain volumes of 20‐year‐old adults who had formed part of a randomised controlled trial of KMC versus incubator care. Multivariate analysis of brain volumes was conducted according to KMC exposure. RESULTS: The study comprised 178 adults born preterm: 97 had received KMC and 81 were incubator care controls. Bivariate analysis showed larger volumes of total grey matter, basal nuclei and cerebellum in those who had received KMC, and the white matter was better organised. This means that the volumes of the main brain structures associated with intelligence, attention, memory and coordination were larger in the KMC group. Multivariate lineal regression analysis demonstrated the direct relationship between brain volumes and duration of KMC, after controlling for potential confounders. CONCLUSION: Our findings suggest that the neuroprotective effects of KMC for preterm infants persisted beyond childhood and improved their lifetime functionality and quality of life.
format Online
Article
Text
id pubmed-9303677
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-93036772022-07-28 Kangaroo mother care had a protective effect on the volume of brain structures in young adults born preterm Charpak, Nathalie Tessier, Rejean Ruiz, Juan Gabriel Uriza, Felipe Hernandez, José Tiberio Cortes, Darwin Montealegre‐Pomar, Adriana Acta Paediatr Original Articles AIM: The protective effects of Kangaroo mother care (KMC) on the neurodevelopment of preterm infants are well established, but we do not know whether the benefits persist beyond infancy. Our aim was to determine whether providing KMC in infancy affected brain volumes in young adulthood. METHOD: Standardised cognitive, memory and motor skills tests were used to determine the brain volumes of 20‐year‐old adults who had formed part of a randomised controlled trial of KMC versus incubator care. Multivariate analysis of brain volumes was conducted according to KMC exposure. RESULTS: The study comprised 178 adults born preterm: 97 had received KMC and 81 were incubator care controls. Bivariate analysis showed larger volumes of total grey matter, basal nuclei and cerebellum in those who had received KMC, and the white matter was better organised. This means that the volumes of the main brain structures associated with intelligence, attention, memory and coordination were larger in the KMC group. Multivariate lineal regression analysis demonstrated the direct relationship between brain volumes and duration of KMC, after controlling for potential confounders. CONCLUSION: Our findings suggest that the neuroprotective effects of KMC for preterm infants persisted beyond childhood and improved their lifetime functionality and quality of life. John Wiley and Sons Inc. 2022-02-01 2022-05 /pmc/articles/PMC9303677/ /pubmed/35067976 http://dx.doi.org/10.1111/apa.16265 Text en © 2022 The Authors. Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles
Charpak, Nathalie
Tessier, Rejean
Ruiz, Juan Gabriel
Uriza, Felipe
Hernandez, José Tiberio
Cortes, Darwin
Montealegre‐Pomar, Adriana
Kangaroo mother care had a protective effect on the volume of brain structures in young adults born preterm
title Kangaroo mother care had a protective effect on the volume of brain structures in young adults born preterm
title_full Kangaroo mother care had a protective effect on the volume of brain structures in young adults born preterm
title_fullStr Kangaroo mother care had a protective effect on the volume of brain structures in young adults born preterm
title_full_unstemmed Kangaroo mother care had a protective effect on the volume of brain structures in young adults born preterm
title_short Kangaroo mother care had a protective effect on the volume of brain structures in young adults born preterm
title_sort kangaroo mother care had a protective effect on the volume of brain structures in young adults born preterm
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303677/
https://www.ncbi.nlm.nih.gov/pubmed/35067976
http://dx.doi.org/10.1111/apa.16265
work_keys_str_mv AT charpaknathalie kangaroomothercarehadaprotectiveeffectonthevolumeofbrainstructuresinyoungadultsbornpreterm
AT tessierrejean kangaroomothercarehadaprotectiveeffectonthevolumeofbrainstructuresinyoungadultsbornpreterm
AT ruizjuangabriel kangaroomothercarehadaprotectiveeffectonthevolumeofbrainstructuresinyoungadultsbornpreterm
AT urizafelipe kangaroomothercarehadaprotectiveeffectonthevolumeofbrainstructuresinyoungadultsbornpreterm
AT hernandezjosetiberio kangaroomothercarehadaprotectiveeffectonthevolumeofbrainstructuresinyoungadultsbornpreterm
AT cortesdarwin kangaroomothercarehadaprotectiveeffectonthevolumeofbrainstructuresinyoungadultsbornpreterm
AT montealegrepomaradriana kangaroomothercarehadaprotectiveeffectonthevolumeofbrainstructuresinyoungadultsbornpreterm