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Non convulsive refractory status epilepticus induced by thiocolchicoside (TCC) intrathecal injection: A case report

TCC is a semisynthetic molecule widely used in clinical settings as a pain killer and myorelaxant. Several neurological side effects have been reported in association with TCC treatment including somnolence, confusion and seizure, the latter in a lower percentage of patients. Some previous reports d...

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Autores principales: Evangelista, Giacomo, Dono, Fedele, Consoli, Stefano, Pozzilli, Valeria, Calisi, Dario, Russo, Mirella, D'Orazio, Claudia, D'Andreagiovanni, Anna, Montesano, Giovanna, Rapini, Sabina, Caulo, Massimo, Onofrj, Marco, Anzellotti, Francesca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303690/
https://www.ncbi.nlm.nih.gov/pubmed/35083767
http://dx.doi.org/10.1111/bcp.15240
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author Evangelista, Giacomo
Dono, Fedele
Consoli, Stefano
Pozzilli, Valeria
Calisi, Dario
Russo, Mirella
D'Orazio, Claudia
D'Andreagiovanni, Anna
Montesano, Giovanna
Rapini, Sabina
Caulo, Massimo
Onofrj, Marco
Anzellotti, Francesca
author_facet Evangelista, Giacomo
Dono, Fedele
Consoli, Stefano
Pozzilli, Valeria
Calisi, Dario
Russo, Mirella
D'Orazio, Claudia
D'Andreagiovanni, Anna
Montesano, Giovanna
Rapini, Sabina
Caulo, Massimo
Onofrj, Marco
Anzellotti, Francesca
author_sort Evangelista, Giacomo
collection PubMed
description TCC is a semisynthetic molecule widely used in clinical settings as a pain killer and myorelaxant. Several neurological side effects have been reported in association with TCC treatment including somnolence, confusion and seizure, the latter in a lower percentage of patients. Some previous reports described seizure onset after TCC intake in adulthood. However, major epileptological complication, namely status epilepticus, has never been previously reported in association with TCC treatment. In our report, we describe a case of acute refractory non‐convulsive status epilepticus (NCSE) in the context of a TCC‐induced acute toxic encephalopathy (ATE) in a woman without any previous neurological or physical comorbidities.
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spelling pubmed-93036902022-07-28 Non convulsive refractory status epilepticus induced by thiocolchicoside (TCC) intrathecal injection: A case report Evangelista, Giacomo Dono, Fedele Consoli, Stefano Pozzilli, Valeria Calisi, Dario Russo, Mirella D'Orazio, Claudia D'Andreagiovanni, Anna Montesano, Giovanna Rapini, Sabina Caulo, Massimo Onofrj, Marco Anzellotti, Francesca Br J Clin Pharmacol Case Reports TCC is a semisynthetic molecule widely used in clinical settings as a pain killer and myorelaxant. Several neurological side effects have been reported in association with TCC treatment including somnolence, confusion and seizure, the latter in a lower percentage of patients. Some previous reports described seizure onset after TCC intake in adulthood. However, major epileptological complication, namely status epilepticus, has never been previously reported in association with TCC treatment. In our report, we describe a case of acute refractory non‐convulsive status epilepticus (NCSE) in the context of a TCC‐induced acute toxic encephalopathy (ATE) in a woman without any previous neurological or physical comorbidities. John Wiley and Sons Inc. 2022-02-08 2022-07 /pmc/articles/PMC9303690/ /pubmed/35083767 http://dx.doi.org/10.1111/bcp.15240 Text en © 2022 The Authors. British Journal of Clinical Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Case Reports
Evangelista, Giacomo
Dono, Fedele
Consoli, Stefano
Pozzilli, Valeria
Calisi, Dario
Russo, Mirella
D'Orazio, Claudia
D'Andreagiovanni, Anna
Montesano, Giovanna
Rapini, Sabina
Caulo, Massimo
Onofrj, Marco
Anzellotti, Francesca
Non convulsive refractory status epilepticus induced by thiocolchicoside (TCC) intrathecal injection: A case report
title Non convulsive refractory status epilepticus induced by thiocolchicoside (TCC) intrathecal injection: A case report
title_full Non convulsive refractory status epilepticus induced by thiocolchicoside (TCC) intrathecal injection: A case report
title_fullStr Non convulsive refractory status epilepticus induced by thiocolchicoside (TCC) intrathecal injection: A case report
title_full_unstemmed Non convulsive refractory status epilepticus induced by thiocolchicoside (TCC) intrathecal injection: A case report
title_short Non convulsive refractory status epilepticus induced by thiocolchicoside (TCC) intrathecal injection: A case report
title_sort non convulsive refractory status epilepticus induced by thiocolchicoside (tcc) intrathecal injection: a case report
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303690/
https://www.ncbi.nlm.nih.gov/pubmed/35083767
http://dx.doi.org/10.1111/bcp.15240
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