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Comparative gene expression study highlights molecular similarities between triple negative breast cancer tumours and feline mammary carcinomas
Triple negative breast cancer (TNBC) is a rare, highly metastatic subtype of breast cancer that typically develops tumours of a high histological grade. As TNBC is negative for the oestrogen, progesterone and HER2 receptors it is also not eligible for targeted hormonal therapies. Therefore, those di...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303714/ https://www.ncbi.nlm.nih.gov/pubmed/35006637 http://dx.doi.org/10.1111/vco.12800 |
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author | Sommerville, Lara Howard, Jane Evans, Shane Kelly, Pamela McCann, Amanda |
author_facet | Sommerville, Lara Howard, Jane Evans, Shane Kelly, Pamela McCann, Amanda |
author_sort | Sommerville, Lara |
collection | PubMed |
description | Triple negative breast cancer (TNBC) is a rare, highly metastatic subtype of breast cancer that typically develops tumours of a high histological grade. As TNBC is negative for the oestrogen, progesterone and HER2 receptors it is also not eligible for targeted hormonal therapies. Therefore, those diagnosed with TNBC are faced with a very poor prognosis. Feline mammary carcinomas (FMCs) have been shown to share key characteristics of TNBC and are being investigated as novel animal models of this disease. A study by Granados‐Soler et al., investigating prognostic markers of FMCs provided the basis of this research, and their prognostic value in TNBC was evaluated using a ‘data‐mining’ research approach. Overall, the comparative genomic aspect of this research identified several potential prognostic markers translatable across TNBC and FMCs. These prognostic markers warrant further investigation in comparative oncology studies. |
format | Online Article Text |
id | pubmed-9303714 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-93037142022-07-28 Comparative gene expression study highlights molecular similarities between triple negative breast cancer tumours and feline mammary carcinomas Sommerville, Lara Howard, Jane Evans, Shane Kelly, Pamela McCann, Amanda Vet Comp Oncol Short Communications Triple negative breast cancer (TNBC) is a rare, highly metastatic subtype of breast cancer that typically develops tumours of a high histological grade. As TNBC is negative for the oestrogen, progesterone and HER2 receptors it is also not eligible for targeted hormonal therapies. Therefore, those diagnosed with TNBC are faced with a very poor prognosis. Feline mammary carcinomas (FMCs) have been shown to share key characteristics of TNBC and are being investigated as novel animal models of this disease. A study by Granados‐Soler et al., investigating prognostic markers of FMCs provided the basis of this research, and their prognostic value in TNBC was evaluated using a ‘data‐mining’ research approach. Overall, the comparative genomic aspect of this research identified several potential prognostic markers translatable across TNBC and FMCs. These prognostic markers warrant further investigation in comparative oncology studies. Blackwell Publishing Ltd 2022-01-14 2022-06 /pmc/articles/PMC9303714/ /pubmed/35006637 http://dx.doi.org/10.1111/vco.12800 Text en © 2022 The Authors. Veterinary and Comparative Oncology published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Communications Sommerville, Lara Howard, Jane Evans, Shane Kelly, Pamela McCann, Amanda Comparative gene expression study highlights molecular similarities between triple negative breast cancer tumours and feline mammary carcinomas |
title | Comparative gene expression study highlights molecular similarities between triple negative breast cancer tumours and feline mammary carcinomas |
title_full | Comparative gene expression study highlights molecular similarities between triple negative breast cancer tumours and feline mammary carcinomas |
title_fullStr | Comparative gene expression study highlights molecular similarities between triple negative breast cancer tumours and feline mammary carcinomas |
title_full_unstemmed | Comparative gene expression study highlights molecular similarities between triple negative breast cancer tumours and feline mammary carcinomas |
title_short | Comparative gene expression study highlights molecular similarities between triple negative breast cancer tumours and feline mammary carcinomas |
title_sort | comparative gene expression study highlights molecular similarities between triple negative breast cancer tumours and feline mammary carcinomas |
topic | Short Communications |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303714/ https://www.ncbi.nlm.nih.gov/pubmed/35006637 http://dx.doi.org/10.1111/vco.12800 |
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