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Increase of the transmission and emittance acceptance through a cyclotron‐based proton therapy gantry

PURPOSE: In proton therapy, the gantry, as the final part of the beamline, has a major effect on beam intensity and beam size at the isocenter. Most of the conventional beam optics of cyclotron‐based proton gantries have been designed with an imaging factor between 1 and 2 from the coupling point (C...

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Autores principales: Maradia, Vivek, Giovannelli, Anna Chiara, Meer, David, Weber, Damien Charles, Lomax, Antony John, Schippers, Jacobus Maarten, Psoroulas, Serena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303721/
https://www.ncbi.nlm.nih.gov/pubmed/35099067
http://dx.doi.org/10.1002/mp.15505
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author Maradia, Vivek
Giovannelli, Anna Chiara
Meer, David
Weber, Damien Charles
Lomax, Antony John
Schippers, Jacobus Maarten
Psoroulas, Serena
author_facet Maradia, Vivek
Giovannelli, Anna Chiara
Meer, David
Weber, Damien Charles
Lomax, Antony John
Schippers, Jacobus Maarten
Psoroulas, Serena
author_sort Maradia, Vivek
collection PubMed
description PURPOSE: In proton therapy, the gantry, as the final part of the beamline, has a major effect on beam intensity and beam size at the isocenter. Most of the conventional beam optics of cyclotron‐based proton gantries have been designed with an imaging factor between 1 and 2 from the coupling point (CP) at the gantry entrance to the isocenter (patient location) meaning that to achieve a clinically desirable (small) beam size at isocenter, a small beam size is also required at the CP. Here we will show that such imaging factors are limiting the emittance which can be transported through the gantry. We, therefore, propose the use of large beam size and low divergence beam at the CP along with an imaging factor of 0.5 (2:1) in a new design of gantry beam optics to achieve substantial improvements in transmission and thus increase beam intensity at the isocenter. METHODS: The beam optics of our gantry have been re‐designed to transport higher emittance without the need of any mechanical modifications to the gantry beamline. The beam optics has been designed using TRANSPORT, with the resulting transmissions being calculated using Monte Carlo simulations (BDSIM code). Finally, the new beam optics have been tested with measurements performed on our Gantry 2 at PSI. RESULTS: With the new beam optics, we could maximize transmission through the gantry for a fixed emittance value. Additionally, we could transport almost four times higher emittance through the gantry compared to conventional optics, whilst achieving good transmissions through the gantry (>50%) with no increased losses in the gantry. As such, the overall transmission (cyclotron to isocenter) can be increased by almost a factor of 6 for low energies. Additionally, the point‐to‐point imaging inherent to the optics allows adjustment of the beam size at the isocenter by simply changing the beam size at the CP. CONCLUSION: We have developed a new gantry beam optics which, by selecting a large beam size and low divergence at the gantry entrance and using an imaging factor of 0.5 (2:1), increases the emittance acceptance of the gantry, leading to a substantial increase in beam intensity at low energies. We expect that this approach could easily be adapted for most types of existing gantries.
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spelling pubmed-93037212022-07-28 Increase of the transmission and emittance acceptance through a cyclotron‐based proton therapy gantry Maradia, Vivek Giovannelli, Anna Chiara Meer, David Weber, Damien Charles Lomax, Antony John Schippers, Jacobus Maarten Psoroulas, Serena Med Phys THERAPEUTIC INTERVENTIONS PURPOSE: In proton therapy, the gantry, as the final part of the beamline, has a major effect on beam intensity and beam size at the isocenter. Most of the conventional beam optics of cyclotron‐based proton gantries have been designed with an imaging factor between 1 and 2 from the coupling point (CP) at the gantry entrance to the isocenter (patient location) meaning that to achieve a clinically desirable (small) beam size at isocenter, a small beam size is also required at the CP. Here we will show that such imaging factors are limiting the emittance which can be transported through the gantry. We, therefore, propose the use of large beam size and low divergence beam at the CP along with an imaging factor of 0.5 (2:1) in a new design of gantry beam optics to achieve substantial improvements in transmission and thus increase beam intensity at the isocenter. METHODS: The beam optics of our gantry have been re‐designed to transport higher emittance without the need of any mechanical modifications to the gantry beamline. The beam optics has been designed using TRANSPORT, with the resulting transmissions being calculated using Monte Carlo simulations (BDSIM code). Finally, the new beam optics have been tested with measurements performed on our Gantry 2 at PSI. RESULTS: With the new beam optics, we could maximize transmission through the gantry for a fixed emittance value. Additionally, we could transport almost four times higher emittance through the gantry compared to conventional optics, whilst achieving good transmissions through the gantry (>50%) with no increased losses in the gantry. As such, the overall transmission (cyclotron to isocenter) can be increased by almost a factor of 6 for low energies. Additionally, the point‐to‐point imaging inherent to the optics allows adjustment of the beam size at the isocenter by simply changing the beam size at the CP. CONCLUSION: We have developed a new gantry beam optics which, by selecting a large beam size and low divergence at the gantry entrance and using an imaging factor of 0.5 (2:1), increases the emittance acceptance of the gantry, leading to a substantial increase in beam intensity at low energies. We expect that this approach could easily be adapted for most types of existing gantries. John Wiley and Sons Inc. 2022-02-14 2022-04 /pmc/articles/PMC9303721/ /pubmed/35099067 http://dx.doi.org/10.1002/mp.15505 Text en © 2022 The Authors. Medical Physics published by Wiley Periodicals LLC on behalf of American Association of Physicists in Medicine. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle THERAPEUTIC INTERVENTIONS
Maradia, Vivek
Giovannelli, Anna Chiara
Meer, David
Weber, Damien Charles
Lomax, Antony John
Schippers, Jacobus Maarten
Psoroulas, Serena
Increase of the transmission and emittance acceptance through a cyclotron‐based proton therapy gantry
title Increase of the transmission and emittance acceptance through a cyclotron‐based proton therapy gantry
title_full Increase of the transmission and emittance acceptance through a cyclotron‐based proton therapy gantry
title_fullStr Increase of the transmission and emittance acceptance through a cyclotron‐based proton therapy gantry
title_full_unstemmed Increase of the transmission and emittance acceptance through a cyclotron‐based proton therapy gantry
title_short Increase of the transmission and emittance acceptance through a cyclotron‐based proton therapy gantry
title_sort increase of the transmission and emittance acceptance through a cyclotron‐based proton therapy gantry
topic THERAPEUTIC INTERVENTIONS
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303721/
https://www.ncbi.nlm.nih.gov/pubmed/35099067
http://dx.doi.org/10.1002/mp.15505
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