Can nebulised HepArin Reduce morTality and time to Extubation in patients with COVID‐19 Requiring invasive ventilation Meta‐Trial (CHARTER‐MT): Protocol and statistical analysis plan for an investigator‐initiated international meta‐trial of prospective randomised clinical studies

There is significant interest in the potential for nebulised unfractionated heparin (UFH), as a novel therapy for patients with COVID‐19 induced acute hypoxaemic respiratory failure requiring invasive ventilation. The scientific and biological rationale for nebulised heparin stems from the evidence...

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Detalles Bibliográficos
Autores principales: van Haren, Frank M. P., Laffey, John G., Artigas, Antonio, Page, Clive, Schultz, Marcus J., Cosgrave, David, McNicholas, Bairbre, Smoot, Thomas L., Nunes, Quentin, Richardson, Alice, Yoon, Hwan‐Jin, van Loon, Lex M., Ghosh, Angajendra, Said, Simone, Panwar, Rakshit, Smith, Roger, Santamaria, John D., Dixon, Barry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303761/
https://www.ncbi.nlm.nih.gov/pubmed/35106809
http://dx.doi.org/10.1111/bcp.15253

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