Profile‐likelihood Bayesian model averaging for two‐sample summary data Mendelian randomization in the presence of horizontal pleiotropy

Two‐sample summary data Mendelian randomization is a popular method for assessing causality in epidemiology, by using genetic variants as instrumental variables. If genes exert pleiotropic effects on the outcome not entirely through the exposure of interest, this can lead to heterogeneous and (poten...

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Detalles Bibliográficos
Autores principales: Shapland, Chin Yang, Zhao, Qingyuan, Bowden, Jack
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303808/
https://www.ncbi.nlm.nih.gov/pubmed/35060160
http://dx.doi.org/10.1002/sim.9320

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303808/
https://www.ncbi.nlm.nih.gov/pubmed/35060160
http://dx.doi.org/10.1002/sim.9320

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