An unexplored angle: T cell antigen discoveries reveal a marginal contribution of proteasome splicing to the immunogenic MHC class I antigen pool

In the current era of T cell–based immunotherapies, it is crucial to understand which types of MHC-presented T cell antigens are produced by tumor cells. In addition to linear peptide antigens, chimeric peptides are generated through proteasome-catalyzed peptide splicing (PCPS). Whether such spliced...

Descripción completa

Detalles Bibliográficos
Autores principales: Verkerk, Tamara, Koomen, Sofie J. I., Fuchs, Kyra J., Griffioen, Marieke, Spaapen, Robbert M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303865/
https://www.ncbi.nlm.nih.gov/pubmed/35858315
http://dx.doi.org/10.1073/pnas.2119736119

Ejemplares similares

Ejemplares similares