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Pharmacologic modulation of intracellular Na(+) concentration with ranolazine impacts inflammatory response in humans and mice

Changes in Ca2(+) influx during proinflammatory stimulation modulates cellular responses, including the subsequent activation of inflammation. Whereas the involvement of Ca(2+) has been widely acknowledged, little is known about the role of Na(+). Ranolazine, a piperazine derivative and established...

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Detalles Bibliográficos
Autores principales:	Lenz, Max, Salzmann, Manuel, Ciotu, Cosmin I., Kaun, Christoph, Krychtiuk, Konstantin A., Rehberger Likozar, Andreja, Sebestjen, Miran, Goederle, Laura, Rauscher, Sabine, Krivaja, Zoriza, Binder, Christoph J., Huber, Kurt, Hengstenberg, Christian, Podesser, Bruno K., Fischer, Michael J. M., Wojta, Johann, Hohensinner, Philipp J., Speidl, Walter S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303949/ https://www.ncbi.nlm.nih.gov/pubmed/35858345 http://dx.doi.org/10.1073/pnas.2207020119

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