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Structure of PLA2R reveals presentation of the dominant membranous nephropathy epitope and an immunogenic patch

Membranous nephropathy is an autoimmune kidney disease caused by autoantibodies targeting antigens present on glomerular podocytes, instigating a cascade leading to glomerular injury. The most prevalent circulating autoantibodies in membranous nephropathy are against phospholipase A2 receptor (PLA2R...

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Detalles Bibliográficos
Autores principales:	Fresquet, Maryline, Lockhart-Cairns, Michael P., Rhoden, Samuel J., Jowitt, Thomas A., Briggs, David C., Baldock, Clair, Brenchley, Paul E., Lennon, Rachel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303975/ https://www.ncbi.nlm.nih.gov/pubmed/35858348 http://dx.doi.org/10.1073/pnas.2202209119

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