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Genetic variation that determines TAPBP expression levels associates with the course of malaria in an HLA allotype-dependent manner

HLA class I (HLA-I) allotypes vary widely in their dependence on tapasin (TAPBP), an integral component of the peptide-loading complex, to present peptides on the cell surface. We identified two single-nucleotide polymorphisms that regulate TAPBP messenger RNA (mRNA) expression in Africans, rs111686...

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Detalles Bibliográficos
Autores principales:	Walker-Sperling, Victoria, Digitale, Jean C., Viard, Mathias, Martin, Maureen P., Bashirova, Arman, Yuki, Yuko, Ramsuran, Veron, Kulkarni, Smita, Naranbhai, Vivek, Li, Hongchuan, Anderson, Stephen K., Yum, Lauren, Clifford, Robert, Kibuuka, Hannah, Ake, Julie, Thomas, Rasmi, Rowland-Jones, Sarah, Rek, John, Arinaitwe, Emmanuel, Kamya, Moses, Rodriguez-Barraquer, Isabel, Feeney, Margaret E., Carrington, Mary
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303992/ https://www.ncbi.nlm.nih.gov/pubmed/35858344 http://dx.doi.org/10.1073/pnas.2205498119

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