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Self-construction of actin networks through phase separation–induced abLIM1 condensates

The abLIM1 is a nonerythroid actin-binding protein critical for stable plasma membrane–cortex interactions under mechanical tension. Its depletion by RNA interference results in sparse, poorly interconnected cortical actin networks and severe blebbing of migrating cells. Its isoforms, abLIM-L, abLIM...

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Detalles Bibliográficos
Autores principales: Yang, Sen, Liu, Chunxia, Guo, Yuting, Li, Guoqing, Li, Dong, Yan, Xiumin, Zhu, Xueliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304016/
https://www.ncbi.nlm.nih.gov/pubmed/35858327
http://dx.doi.org/10.1073/pnas.2122420119