Targeting oncogenic KRAS with molecular brush-conjugated antisense oligonucleotides

The mutant form of the guanosine triphosphatase (GTPase) KRAS is a key driver in human tumors but remains a challenging therapeutic target, making KRAS(MUT) cancers a highly unmet clinical need. Here, we report a class of bottlebrush polyethylene glycol (PEG)–conjugated antisense oligonucleotides (A...

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Detalles Bibliográficos
Autores principales: Wang, Dali, Wang, Qiwei, Wang, Yuyan, Chen, Peiru, Lu, Xueguang, Jia, Fei, Sun, Yehui, Sun, Tingyu, Zhang, Lei, Che, Fangyuan, He, Jialu, Lian, Liming, Morano, Gemma, Shen, Michael, Ren, Mengqi, Dong, Sijia S., Zhao, Jean J., Zhang, Ke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Physical Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304022/
https://www.ncbi.nlm.nih.gov/pubmed/35858356
http://dx.doi.org/10.1073/pnas.2113180119

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