A versatile fluorescence-quenched substrate for quantitative measurement of glucocerebrosidase activity within live cells

Loss of activity of the lysosomal glycosidase β-glucocerebrosidase (GCase) causes the lysosomal storage disease Gaucher disease (GD) and has emerged as the greatest genetic risk factor for the development of both Parkinson disease (PD) and dementia with Lewy bodies. There is significant interest int...

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Detalles Bibliográficos
Autores principales: Deen, Matthew C., Zhu, Yanping, Gros, Christina, Na, Na, Gilormini, Pierre-André, Shen, David L., Bhosale, Sandeep, Anastasi, Nadia, Wang, RuiQi, Shan, Xiaoyang, Harde, Eva, Jagasia, Ravi, Lynn, Francis C., Vocadlo, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Physical Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304032/
https://www.ncbi.nlm.nih.gov/pubmed/35858317
http://dx.doi.org/10.1073/pnas.2200553119

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