Clostridioides difficile toxin B alone and with pro-inflammatory cytokines induces apoptosis in enteric glial cells by activating three different signalling pathways mediated by caspases, calpains and cathepsin B

Clostridioides difficile infection (CDI) causes nosocomial/antibiotic-associated gastrointestinal diseases with dramatically increasing global incidence and mortality rates. The main C. difficile virulence factors, toxins A and B (TcdA/TcdB), cause cytopathic/cytotoxic effects and inflammation. We d...

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Detalles Bibliográficos
Autores principales: Fettucciari, Katia, Marguerie, Flavien, Fruganti, Alessandro, Marchegiani, Andrea, Spaterna, Andrea, Brancorsini, Stefano, Marconi, Pierfrancesco, Bassotti, Gabrio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304068/
https://www.ncbi.nlm.nih.gov/pubmed/35864342
http://dx.doi.org/10.1007/s00018-022-04459-z

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