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Making sense of phantom limb pain

Phantom limb pain (PLP) impacts the majority of individuals who undergo limb amputation. The PLP experience is highly heterogenous in its quality, intensity, frequency and severity. This heterogeneity, combined with the low prevalence of amputation in the general population, has made it difficult to...

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Autores principales: Schone, Hunter R, Baker, Chris I, Katz, Joel, Nikolajsen, Lone, Limakatso, Katleho, Flor, Herta, Makin, Tamar R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304093/
https://www.ncbi.nlm.nih.gov/pubmed/35609964
http://dx.doi.org/10.1136/jnnp-2021-328428
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author Schone, Hunter R
Baker, Chris I
Katz, Joel
Nikolajsen, Lone
Limakatso, Katleho
Flor, Herta
Makin, Tamar R
author_facet Schone, Hunter R
Baker, Chris I
Katz, Joel
Nikolajsen, Lone
Limakatso, Katleho
Flor, Herta
Makin, Tamar R
author_sort Schone, Hunter R
collection PubMed
description Phantom limb pain (PLP) impacts the majority of individuals who undergo limb amputation. The PLP experience is highly heterogenous in its quality, intensity, frequency and severity. This heterogeneity, combined with the low prevalence of amputation in the general population, has made it difficult to accumulate reliable data on PLP. Consequently, we lack consensus on PLP mechanisms, as well as effective treatment options. However, the wealth of new PLP research, over the past decade, provides a unique opportunity to re-evaluate some of the core assumptions underlying what we know about PLP and the rationale behind PLP treatments. The goal of this review is to help generate consensus in the field on how best to research PLP, from phenomenology to treatment. We highlight conceptual and methodological challenges in studying PLP, which have hindered progress on the topic and spawned disagreement in the field, and offer potential solutions to overcome these challenges. Our hope is that a constructive evaluation of the foundational knowledge underlying PLP research practices will enable more informed decisions when testing the efficacy of existing interventions and will guide the development of the next generation of PLP treatments.
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spelling pubmed-93040932022-08-11 Making sense of phantom limb pain Schone, Hunter R Baker, Chris I Katz, Joel Nikolajsen, Lone Limakatso, Katleho Flor, Herta Makin, Tamar R J Neurol Neurosurg Psychiatry Cognitive Neurology Phantom limb pain (PLP) impacts the majority of individuals who undergo limb amputation. The PLP experience is highly heterogenous in its quality, intensity, frequency and severity. This heterogeneity, combined with the low prevalence of amputation in the general population, has made it difficult to accumulate reliable data on PLP. Consequently, we lack consensus on PLP mechanisms, as well as effective treatment options. However, the wealth of new PLP research, over the past decade, provides a unique opportunity to re-evaluate some of the core assumptions underlying what we know about PLP and the rationale behind PLP treatments. The goal of this review is to help generate consensus in the field on how best to research PLP, from phenomenology to treatment. We highlight conceptual and methodological challenges in studying PLP, which have hindered progress on the topic and spawned disagreement in the field, and offer potential solutions to overcome these challenges. Our hope is that a constructive evaluation of the foundational knowledge underlying PLP research practices will enable more informed decisions when testing the efficacy of existing interventions and will guide the development of the next generation of PLP treatments. BMJ Publishing Group 2022-08 2022-05-24 /pmc/articles/PMC9304093/ /pubmed/35609964 http://dx.doi.org/10.1136/jnnp-2021-328428 Text en © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.
spellingShingle Cognitive Neurology
Schone, Hunter R
Baker, Chris I
Katz, Joel
Nikolajsen, Lone
Limakatso, Katleho
Flor, Herta
Makin, Tamar R
Making sense of phantom limb pain
title Making sense of phantom limb pain
title_full Making sense of phantom limb pain
title_fullStr Making sense of phantom limb pain
title_full_unstemmed Making sense of phantom limb pain
title_short Making sense of phantom limb pain
title_sort making sense of phantom limb pain
topic Cognitive Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304093/
https://www.ncbi.nlm.nih.gov/pubmed/35609964
http://dx.doi.org/10.1136/jnnp-2021-328428
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