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Pharmacokinetic Interaction Between the MEK1/MEK2 Inhibitor Trametinib and Oral Contraceptives Containing Norethindrone and Ethinyl Estradiol in Female Patients With Solid Tumors

This phase 1 postapproval study assessed the effect of the mitogen‐activated protein kinase kinase enzyme 1/enzyme 2 inhibitor trametinib (2 mg once daily, repeat dosing) on the pharmacokinetics of combined oral contraceptives (COCs) containing norethindrone (NE; 1 mg daily) and ethinyl estradiol (E...

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Detalles Bibliográficos
Autores principales:	Arkenau, Hendrik‐Tobias, Taylor, Donatienne, Xu, Xiaoying, Chitnis, Shripad, Llacer‐Perez, Casilda, Moore, Kathleen, Nidamarthy, Prasanna Kumar, Ilankumaran, Palanichamy, De Vos‐Geelen, Judith
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304124/ https://www.ncbi.nlm.nih.gov/pubmed/35157784 http://dx.doi.org/10.1002/cpdd.1052

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