The novel persistent sodium current inhibitor PRAX‐562 has potent anticonvulsant activity with improved protective index relative to standard of care sodium channel blockers

OBJECTIVE: This study investigates the effects of PRAX‐562 on sodium current (I(Na)), intrinsic neuronal excitability, and protection from evoked seizures to determine whether a preferential persistent I(Na) inhibitor would exhibit improved preclinical efficacy and tolerability compared to two stand...

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Detalles Bibliográficos
Autores principales: Kahlig, Kristopher M., Scott, Liam, Hatch, Robert J., Griffin, Andrew, Martinez Botella, Gabriel, Hughes, Zoë A., Wittmann, Marion
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304232/
https://www.ncbi.nlm.nih.gov/pubmed/35037706
http://dx.doi.org/10.1111/epi.17149

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304232/
https://www.ncbi.nlm.nih.gov/pubmed/35037706
http://dx.doi.org/10.1111/epi.17149

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