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The novel persistent sodium current inhibitor PRAX‐562 has potent anticonvulsant activity with improved protective index relative to standard of care sodium channel blockers

OBJECTIVE: This study investigates the effects of PRAX‐562 on sodium current (I(Na)), intrinsic neuronal excitability, and protection from evoked seizures to determine whether a preferential persistent I(Na) inhibitor would exhibit improved preclinical efficacy and tolerability compared to two stand...

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Detalles Bibliográficos
Autores principales:	Kahlig, Kristopher M., Scott, Liam, Hatch, Robert J., Griffin, Andrew, Martinez Botella, Gabriel, Hughes, Zoë A., Wittmann, Marion
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304232/ https://www.ncbi.nlm.nih.gov/pubmed/35037706 http://dx.doi.org/10.1111/epi.17149

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