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Relating Conformational Equilibria to Conformer‐Specific Lipophilicities: New Opportunities in Drug Discovery

Efficient drug discovery is based on a concerted effort in optimizing bioactivity and compound properties such as lipophilicity, and is guided by efficiency metrics that reflect both aspects. While conformation–activity relationships and ligand conformational control are known strategies to improve...

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Detalles Bibliográficos
Autores principales:	Linclau, Bruno, Wang, Zhong, Jeffries, Benjamin, Graton, Jérôme, Carbajo, Rodrigo J., Sinnaeve, Davy, Le Questel, Jean‐Yves, Scott, James S., Chiarparin, Elisabetta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304282/ https://www.ncbi.nlm.nih.gov/pubmed/34913249 http://dx.doi.org/10.1002/anie.202114862

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